Zimistobart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 06:30:13 GMT 2025` Edited by `admin` on `Wed Apr 02 06:30:13 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	C41SJ1JYR1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G1 [235-alanine,236-glutamic acid,238-alanine,de-C-terminal lysine], anti-(human killer cell lectin-like receptor KLRC1) (human monoclonal NKG2a.9-g1.3f ?1-chain), disulfide with human monoclonal NKG2a.9-g1.3f ?-chain, dimer

Preferred Name

English

Zimistobart

Official Name

English

BMS-986315

Code

English

BMS 986315 [WHO-DD]

Common Name

English

Anti-NKG2A mAb

Common Name

English

BMS-986315-01

Code

English

Code System Code Type Description

SMS_ID

300000013762

Created by admin on Wed Apr 02 06:30:13 GMT 2025 , Edited by admin on Wed Apr 02 06:30:13 GMT 2025

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FDA UNII

C41SJ1JYR1

Created by admin on Wed Apr 02 06:30:13 GMT 2025 , Edited by admin on Wed Apr 02 06:30:13 GMT 2025

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NCI_THESAURUS

C176867

Created by admin on Wed Apr 02 06:30:13 GMT 2025 , Edited by admin on Wed Apr 02 06:30:13 GMT 2025

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CAS

2829290-06-2

Created by admin on Wed Apr 02 06:30:13 GMT 2025 , Edited by admin on Wed Apr 02 06:30:13 GMT 2025

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USAN

LM-85

Created by admin on Wed Apr 02 06:30:13 GMT 2025 , Edited by admin on Wed Apr 02 06:30:13 GMT 2025

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INN

12978

Created by admin on Wed Apr 02 06:30:13 GMT 2025 , Edited by admin on Wed Apr 02 06:30:13 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_145	2_201
2_221	4_214
2_262	2_322
1_145	1_201
2_368	2_426
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_221	3_214
1_227	2_227
1_230	2_230
1_262	1_322
1_368	1_426

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					PI49HI2X2K

NKG2-A/NKG2-B TYPE II INTEGRAL MEMBRANE PROTEIN

TARGET -> INHIBITOR

Comments:

Inhibits the interaction between HLA-E and the NKG2A receptor. Inhibition of the NKG2A-HLA-E interaction blocks the HLA-E-mediated inhibitory NKG2A signal and is hypothesized to restore both T and NK cell antitumor responses

Amount:

Related Record Type Details


					C41SJ1JYR1

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL