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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C5H6NO3.Zn
Molecular Weight 321.621
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC PIDOLATE

SMILES

[Zn++].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]2CCC(=O)N2

InChI

InChIKey=OWVLYQRCCIEOPF-QHTZZOMLSA-L
InChI=1S/2C5H7NO3.Zn/c2*7-4-2-1-3(6-4)5(8)9;/h2*3H,1-2H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*3-;/m00./s1

HIDE SMILES / InChI

Molecular Formula C5H6NO3
Molecular Weight 128.106
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Zn
Molecular Weight 65.409
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Pidolic acid (pyroglutamic acid) is natural amino acid derivative in which the the free amino group of glutamic acid cyclizes to form a lactam. Sodium salt of pyroglutamic acid is used in cosmetics as a moisturizer for dry skin.

CNS Activity

Curator's Comment: Known to penetrate blood-brain barrier in rats. Is produced naturally in human brain

Originator

Sources: Haitinger, L.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel

Approved Use

Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne.

Launch Date

1.34256958E12
Primary
Unknown

Approved Use

Unknown
Primary
EcoCare™ Zinclean

Approved Use

Use in anti-dandruff shampoos
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Stability and CTL activity of N-terminal glutamic acid containing peptides.
2001 Jun
Stability and CTL-activity of P40/ELA melanoma vaccine candidate.
2001 Sep-Dec
The X-ray crystal structure of pyrrolidone-carboxylate peptidase from hyperthermophilic archaea Pyrococcus horikoshii.
2002
Continuous spectrometric assays for glutaminyl cyclase activity.
2002 Apr 1
Complete structure of an increasing capillary permeability protein (ICPP) purified from Vipera lebetina venom. ICPP is angiogenic via vascular endothelial growth factor receptor signalling.
2002 Aug 16
The primary structure of cassowary (Casuarius casuarius) goose type lysozyme.
2002 Jan
Characterization and sequence of tomato 2S seed albumin: a storage protein with sequence similarities to the fruit lectin.
2003 Apr
Solution structure of the cytotoxic RNase 4 from oocytes of bullfrog Rana catesbeiana.
2003 Feb 28
Reinvestigation of the proposed folding and self-association of the Neuropeptide Head Activator.
2003 Mar
[Evolution of the neuroprotection concept].
2003 Mar-Apr
Proinsulin C-peptide and its C-terminal pentapeptide: degradation in human serum and Schiff base formation with subsequent CO2 incorporation.
2003 May
Expression, purification, and characterization of avian Thy-1 from Lec1 mammalian and Tn5 insect cells.
2004 Feb
Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry.
2004 Feb 24
Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures.
2004 Mar-Apr
Synthesis of (2S,3R)-[3',3',3'-2H3]-valine and (2S,3S)-4-fluorovaline.
2004 May 7
A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition.
2005
The computer modelling of human TRH receptor, TRH and TRH-like peptides.
2005
Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes.
2005 Apr
Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.
2005 Aug 2
Nanoparticles on the basis of highly functionalized dextrans.
2005 Aug 3
Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.
2005 Aug 7
Physiological and pathological aspects of GSH metabolism.
2005 Feb
CLPM: a cross-linked peptide mapping algorithm for mass spectrometric analysis.
2005 Jul 15
Patents

Sample Use Guides

Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne.
Route of Administration: Topical
When normal human dermal fibroblasts were irradiated with UVA after a pre-treatment with 10 uM of Zinc Pidolate (Zinc PCA) for 16 h, this pretreatment suppressed the UVA-induced c-Fos expression to 110%, in comparison with the value of 200% obtained without such Zinc PCA pre-treatment. Zinc PCA induced SVCT2 mRNA expression in NHDFs in a dose-dependent manner, i.e., 115% at 25 uM and 125% at 50 uM, in comparison with the control.
Substance Class Chemical
Created
by admin
on Thu Jul 06 02:21:25 UTC 2023
Edited
by admin
on Thu Jul 06 02:21:25 UTC 2023
Record UNII
C32PQ86DH4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZINC PIDOLATE
WHO-DD  
Common Name English
ZINC PCA
INCI  
INCI  
Official Name English
ZINC, BIS(5-OXO-L-PROLINATO)-
Common Name English
ZINC PCA [INCI]
Common Name English
ZINC PYRROLIDONE CARBOXYLATE
Common Name English
ZINC PYRROLIDONECARBOXYLATE
Common Name English
ZINC PYROGLUTAMATE
Common Name English
ZINC L-PYROGLUTAMATE
Common Name English
PROLINE, 5-OXO-, ZINC SALT (2:1), L-
Common Name English
Zinc Pidolate [WHO-DD]
Common Name English
Code System Code Type Description
PUBCHEM
11602214
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY
DAILYMED
C32PQ86DH4
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY
EVMPD
SUB26632
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY
EPA CompTox
DTXSID40935009
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY
CAS
15454-75-8
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY
DRUG BANK
DBSALT001565
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY
SMS_ID
100000090155
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY
RXCUI
1426280
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY RxNorm
FDA UNII
C32PQ86DH4
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY
ECHA (EC/EINECS)
239-473-5
Created by admin on Thu Jul 06 02:21:26 UTC 2023 , Edited by admin on Thu Jul 06 02:21:26 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE