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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C5H6NO3.Zn
Molecular Weight 321.621
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINC PIDOLATE

SMILES

[Zn++].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]2CCC(=O)N2

InChI

InChIKey=OWVLYQRCCIEOPF-QHTZZOMLSA-L
InChI=1S/2C5H7NO3.Zn/c2*7-4-2-1-3(6-4)5(8)9;/h2*3H,1-2H2,(H,6,7)(H,8,9);/q;;+2/p-2/t2*3-;/m00./s1

HIDE SMILES / InChI

Molecular Formula C5H6NO3
Molecular Weight 128.106
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Zn
Molecular Weight 65.409
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Zinc Pidolate (Zinc PCA) is a topical skin product with purifying, astingent, anti-inflammatory, antiseptic activity. It has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. Zinc Pidolate has also being shown to be effective against halitosis. Zinc PCA prevents the UV-induced MMP-1 production in vitro by suppressing the activation of AP-1. Zinc PCA was also able to enhance type I collagen synthesis in NHDFs, by increasing the expression of the mRNA encoding the ascorbic acid transporter SVCT2 in non-UV irradiated NHDFs, which suggests its promising effect against not only photoaged skin but also for the simple atrophic change of intrinsic skin ageing. Zinc PCA is able to suppress sebum secretion by inhibiting 5-α reductase in hyperseborrhea, to suppress body odor by forming zinc salts with short-chain fatty acids, to suppress wrinkles by inhibiting AP-1 to and inhibit bacterial growth including acne related Propionibacterium acnes.

CNS Activity

Curator's Comment: Known to penetrate blood-brain barrier in rats. Is produced naturally in human brain

Originator

Sources: Haitinger, L.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel

Approved Use

Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne.

Launch Date

2012
Primary
Unknown

Approved Use

Unknown
Primary
EcoCare™ Zinclean

Approved Use

Use in anti-dandruff shampoos
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Electrophilic fluorination of pyroglutamic acid derivatives: application of substrate-dependent reactivity and diastereoselectivity to the synthesis of optically active 4-fluoroglutamic acids.
2001 Dec 28
Stability and CTL activity of N-terminal glutamic acid containing peptides.
2001 Jun
Characterization of cigar tobaccos by gas chromatographic/mass spectrometric analysis of nonvolatile organic acids: application to the authentication of Cuban cigars.
2001 Mar
The mechanism of aubstrate eecognition of pyroglutamyl-peptidase I from Bacillus amyloliquefaciens as determined by X-ray crystallography and site-directed mutagenesis.
2001 May 25
Allatostatins of the tiger prawn, Penaeus monodon (Crustacea: Penaeidea).
2002 Jun
Two novel antifungal peptides distinct with a five-disulfide motif from the bark of Eucommia ulmoides Oliv.
2002 Jun 19
[Effect of a drug composition containing pyroglutamic acid and pyrrolidone on the cerebral circulation].
2002 May-Jun
Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity.
2002 Sep 3
Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters.
2002 Sep 6
Characterization and sequence of tomato 2S seed albumin: a storage protein with sequence similarities to the fruit lectin.
2003 Apr
Refolding of amphioxus insulin-like peptide: implications of a bifurcating evolution of the different folding behavior of insulin and insulin-like growth factor 1.
2003 Aug 19
[Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone].
2003 Jan-Feb
Characterization of a new bradykinin-potentiating peptide (TmF) from Trimeresurus mucrosquamatus.
2003 Jul
Pyrrolidinones derived from (S)-pyroglutamic acid: penmacric acid and analogues.
2003 Jul 7
Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site.
2004 Feb 10
Synthesis of (2S,3S)-3'-fluoroisoleucine.
2004 Mar 7
Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells.
2004 Oct 15
Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).
2004 Sep
The computer modelling of human TRH receptor, TRH and TRH-like peptides.
2005
Nanoparticles on the basis of highly functionalized dextrans.
2005 Aug 3
Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.
2005 Aug 7
Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).
2005 Jul
Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom.
2005 Jul
Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides.
2005 May
Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques.
2005 Nov 4
Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme.
2005 Sep
Synthesis of 1,3-dioxo-hexahydropyrido[1,2-c][1,3]diazepine carboxylates, a new bicyclic skeleton formed by ring expansion-RCM methodology.
2005 Sep 21
Thermostability and in vitro digestibility of a purified major allergen 2S albumin (Ses i 1) from white sesame seeds (Sesamum indicum L.).
2005 Sep 25
CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.
2006 Feb
Patents

Sample Use Guides

In Vivo Use Guide
Sources: Topical, as a compontent of lotions, creams and other cosmetic products.
Topical, as a compontent of lotions, creams and other cosmetic products.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:13:39 GMT 2023
Edited
by admin
on Fri Dec 15 19:13:39 GMT 2023
Record UNII
C32PQ86DH4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ZINC PIDOLATE
WHO-DD  
Common Name English
ZINC PCA
INCI  
INCI  
Official Name English
ZINC, BIS(5-OXO-L-PROLINATO)-
Common Name English
ZINC PCA [INCI]
Common Name English
ZINC PYRROLIDONE CARBOXYLATE
Common Name English
ZINC PYRROLIDONECARBOXYLATE
Common Name English
ZINC PYROGLUTAMATE
Common Name English
ZINC L-PYROGLUTAMATE
Common Name English
PROLINE, 5-OXO-, ZINC SALT (2:1), L-
Common Name English
Zinc Pidolate [WHO-DD]
Common Name English
Code System Code Type Description
PUBCHEM
11602214
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY
DAILYMED
C32PQ86DH4
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY
EVMPD
SUB26632
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY
EPA CompTox
DTXSID40935009
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY
CAS
15454-75-8
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY
DRUG BANK
DBSALT001565
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY
SMS_ID
100000090155
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY
RXCUI
1426280
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY RxNorm
FDA UNII
C32PQ86DH4
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY
ECHA (EC/EINECS)
239-473-5
Created by admin on Fri Dec 15 19:13:39 GMT 2023 , Edited by admin on Fri Dec 15 19:13:39 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE