Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H12N2S2.ClH |
| Molecular Weight | 188.742 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NCCSSCCN
InChI
InChIKey=NULDEVQACXJZLL-UHFFFAOYSA-N
InChI=1S/C4H12N2S2.ClH/c5-1-3-7-8-4-2-6;/h1-6H2;1H
| Molecular Formula | C4H12N2S2 |
| Molecular Weight | 152.281 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Hyperhomocysteinemia and low plasma folate as risk factors for central retinal vein occlusion: a case-control study in a Chinese population. | 2006-10 |
|
| Capillary electrophoresis method development for determination of impurities in sodium cysteamine phosphate samples. | 2006-09-11 |
|
| Neuroprotective effects of cystamine in aged parkinsonian mice. | 2006-06 |
|
| The protective effects of cystamine in the R6/2 Huntington's disease mouse involve mechanisms other than the inhibition of tissue transglutaminase. | 2006-06 |
|
| Transglutaminase activity regulates osteoblast differentiation and matrix mineralization in MC3T3-E1 osteoblast cultures. | 2006-04 |
|
| CYTE-I-HD: phase I dose finding and tolerability study of cysteamine (Cystagon) in Huntington's disease. | 2006-04 |
|
| Stepwise assembly of acceptor--sigma spacer--donor monolayers: preparation and electrochemical characterization. | 2006-03-28 |
|
| Mechanistic insight provided by glutaredoxin within a fusion to redox-sensitive yellow fluorescent protein. | 2006-02-21 |
|
| The p53 oncoprotein is a substrate for tissue transglutaminase kinase activity. | 2006-01-13 |
|
| [Lorentz Eldjarn--a catalyst for chemistry in Norwegian medicine]. | 2005-12-15 |
|
| Identification of an inactivating cysteine switch in protein kinase Cepsilon, a rational target for the design of protein kinase Cepsilon-inhibitory cancer therapeutics. | 2005-11-15 |
|
| Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease. | 2005-10 |
|
| A novel small molecule CFTR inhibitor attenuates HCO3- secretion and duodenal ulcer formation in rats. | 2005-10 |
|
| Covalent attachment of glucose oxidase to an Au electrode modified with gold nanoparticles for use as glucose biosensor. | 2005-09 |
|
| Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease. | 2005-08 |
|
| Phenoxybenzamine and benextramine, but not 4-diphenylacetoxy-N-[2-chloroethyl]piperidine hydrochloride, display irreversible noncompetitive antagonism at G protein-coupled receptors. | 2005-08 |
|
| A general fluorescence-based coupled assay for S-adenosylmethionine-dependent methyltransferases. | 2005-05-27 |
|
| Construction of a tethered poly(ethylene glycol) surface gradient for studies of cell adhesion kinetics. | 2005-05-24 |
|
| Post-translational disulfide modifications in cell signaling--role of inter-protein, intra-protein, S-glutathionyl, and S-cysteaminyl disulfide modifications in signal transmission. | 2005-05 |
|
| Determination of total cysteamine in human plasma in the form of its 2-S-quinolinium derivative by high performance liquid chromatography. | 2005-05 |
|
| Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease. | 2005-04-15 |
|
| Pharmacokinetics and tissue retention of (Gd-DTPA)-cystamine copolymers, a biodegradable macromolecular magnetic resonance imaging contrast agent. | 2005-04 |
|
| Glutathione synthesis in Streptococcus agalactiae. One protein accounts for gamma-glutamylcysteine synthetase and glutathione synthetase activities. | 2005-03-25 |
|
| Mechanism for the inhibition of transglutaminase 2 by cystamine. | 2005-03-15 |
|
| Resistance of zwitterionic telomers accumulated on metal surfaces against nonspecific adsorption of proteins. | 2005-02-15 |
|
| Characterization of purified rat testicular transglutaminase and age-dependent changes of the enzyme activities. | 2005-02 |
|
| Small artery remodeling depends on tissue-type transglutaminase. | 2005-01-07 |
|
| Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3. | 2005-01 |
|
| Formulation and surface modification of poly(ester-anhydride) micro- and nanospheres. | 2005-01 |
|
| The influence of methylene blue on the spontaneous contractity of the non-pregnant human myometrium and on the myometrial response to DEA/NO. | 2005 |
|
| Poly(ethylene oxide)-b-poly(N-isopropylacrylamide) nanoparticles with cross-linked cores as drug carriers. | 2005 |
|
| Different inhibition characteristics of intracellular transglutaminase activity by cystamine and cysteamine. | 2004-12-31 |
|
| Isolation and functional characterization of a cyst(e)amine-sensitive protein protecting methyl-dithio groups. | 2004-12 |
|
| Interrelationships among microbiological, physicochemical, and biochemical properties of Terrincho cheese, with emphasis on biogenic amines. | 2004-12 |
|
| Fishing of beta-amylase with a SAM of alpha-cyclodextrin-poly- (ethylene glycol) conjugate. | 2004-11-15 |
|
| Cell-based assay for monitoring transglutaminase activity. | 2004-10-15 |
|
| Amperometric cholesterol biosensor based on in situ reconstituted cholesterol oxidase on an immobilized monolayer of flavin adenine dinucleotide cofactor. | 2004-10-01 |
|
| Production of dromedary (Camelus dromedarius) embryos by IVM and IVF and co-culture with oviductal or granulosa cells. | 2004-10-01 |
|
| Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation. | 2004-10 |
|
| Arabidopsis thaliana glutamate-cysteine ligase: functional properties, kinetic mechanism, and regulation of activity. | 2004-08-06 |
|
| Dependence of Giardia lamblia encystation on novel transglutaminase activity. | 2004-08 |
|
| Synthesis, structure and electrochemistry of ferrocene-peptide macrocycles. | 2004-06-07 |
|
| Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. | 2004-06-04 |
|
| Tissue transglutaminase has intrinsic kinase activity: identification of transglutaminase 2 as an insulin-like growth factor-binding protein-3 kinase. | 2004-06-04 |
|
| Asialoerythropoietin is not effective in the R6/2 line of Huntington's disease mice. | 2004-05-10 |
|
| Accumulation of phenyl boronic acid-carrying telomers on a gold surface. | 2004-05-01 |
|
| Transglutaminases - possible drug targets in human diseases. | 2004-04 |
|
| Protective role of tissue transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells. | 2004-03-31 |
|
| Radioprotective effects of amifostine (WR-2721) or cystamine on radiation damage and its repair in rats whole body exposed to fission neutrons. | 2004 |
|
| Molecular recognition of avidin on biotin-functionalized gold surfaces detected by FT-IRRAS and use of metal carbonyl probes. | 2002-01-01 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 17:36:13 GMT 2025
by
admin
on
Wed Apr 02 17:36:13 GMT 2025
|
| Record UNII |
C2U867X2F7
|
| Record Status |
Validated (UNII)
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| Record Version |
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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167628
Created by
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613802
Created by
admin on Wed Apr 02 17:36:13 GMT 2025 , Edited by admin on Wed Apr 02 17:36:13 GMT 2025
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C2U867X2F7
Created by
admin on Wed Apr 02 17:36:13 GMT 2025 , Edited by admin on Wed Apr 02 17:36:13 GMT 2025
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1072-22-6
Created by
admin on Wed Apr 02 17:36:13 GMT 2025 , Edited by admin on Wed Apr 02 17:36:13 GMT 2025
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
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