TRITICONAZOLE

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H20ClN3O
Molecular Weight	317.813
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)CC\C(=C/C2=CC=C(Cl)C=C2)C1(O)CN3C=NC=N3

InChI

InChIKey=PPDBOQMNKNNODG-NTEUORMPSA-N

InChI=1S/C17H20ClN3O/c1-16(2)8-7-14(9-13-3-5-15(18)6-4-13)17(16,22)10-21-12-19-11-20-21/h3-6,9,11-12,22H,7-8,10H2,1-2H3/b14-9+

HIDE SMILES / InChI

Molecular Formula	C17H20ClN3O
Molecular Weight	317.813
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	1
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20708073 | https://www.ncbi.nlm.nih.gov/pubmed/10564047 | http://search.fytoweb.be/NL/doc/Triticonazole_EFSA_conclusion_final.pdf

Triticonazole is a triazole pesticide/fungicide with broad antifungal activity. Like many azole fungicides, triticonazole likely inhibits 14-α demethylase, inhibiting ergosterol production and fungal cell wall synthesis. Additionally, triticonazole may inhibit aromatase.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Direct enantioseparation of nitrogen-heterocyclic pesticides on cellulose-based chiral column by high-performance liquid chromatography.	2015 Jan	25331721

Patents

Sample Use Guides

In Vivo Use Guide

Experiments for evaluation of the toxic effects of triticonazole in one control and three experimental groups of pigs, treated orally via a gastic tube at increasing doses of 200 mg/kg, 1000 mg/kg and 2000 mg/kg (0.1LD50, 0.5LD50 and LD50 respectively) were performed.

Route of Administration: Oral

In Vitro Use Guide

Amendment of the medium to pH 4 promoted growth of S. homoeocarpa in the absence of fungicides and enhanced pathogen growth relative to contaminant isolates on medium amended with 0.1 ug/ml triticonazole or 5 ug/mL azoxystrobin.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:21:36 GMT 2023` Edited by `admin` on `Sat Dec 16 08:21:36 GMT 2023`
Record UNII	C2O101E6G4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRITICONAZOLE

Common Name

English

TRITICONAZOLE [ISO]

Common Name

English

RAC-(1R,5E)-5-((4-CHLOROPHENYL)METHYLIDENE)-2,2-DIMETHYL-1-(1H-1,2,4-TRIAZOL-1-YLMETHYL)CYCLOPENTAN-1-OL

Systematic Name

English

PREMISE

Brand Name

English

CHARTER

Brand Name

English

(RS)-(E)-5-(4-CHLOROBENZYLIDENE)-2,2-DIMETHYL-1-(1H-1,2,4-TRIAZOL-1-YLMETHYL)CYCLOPENTANOL

Systematic Name

English

PREMIS

Brand Name

English

ALIOS

Brand Name

English

Code System Code Type Description

HSDB

7944