TILSUPROST

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H33NO4S
Molecular Weight	383.545
Optical Activity	( + / - )
Defined Stereocenters	5 / 5
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2N=C(C[C@H]12)SCCCC(=O)OC

InChI

InChIKey=TUOQTRVLPKMMDB-RQGIMTSLSA-N

InChI=1S/C20H33NO4S/c1-3-4-5-7-14(22)9-10-15-16-12-19(21-17(16)13-18(15)23)26-11-6-8-20(24)25-2/h9-10,14-18,22-23H,3-8,11-13H2,1-2H3/b10-9+/t14-,15-,16-,17+,18-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H33NO4S
Molecular Weight	383.545
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8876659

Tilsuprost is an iminoprostacyclin derivative patented by Hoechst A.-G. as stable prostacyclin analog useful cytoprotective agent. In preclinical models, Tilsuprost given just before induction of pancreatitis partly prevented the impairment of mitochondrial oxidative and phosphorylative functions, however, these positive effects were limited in acute pancreatitis preceded by acute ethanol intake.

Originator

Approval Year

PubMed

Title	Date	PubMed
The effect of tilsuprost on the liver mitochondria in taurocholate pancreatitis in rats with antecedent acute ethanol abuse.	1996	8876659

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:31:07 GMT 2025` Edited by `admin` on `Wed Apr 02 08:31:07 GMT 2025`
Record UNII	C23W8PF2D4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

tilsuprost [INN]

Preferred Name

English

TILSUPROST

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78568