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Details

Stereochemistry ACHIRAL
Molecular Formula C9H8N2S.ClH
Molecular Weight 212.699
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2-AMINO-4-PHENYLTHIAZOLE MONOHYDROCHLORIDE

SMILES

Cl.NC1=NC(=CS1)C2=CC=CC=C2

InChI

InChIKey=KXSYGCGRAVSMBT-UHFFFAOYSA-N
InChI=1S/C9H8N2S.ClH/c10-9-11-8(6-12-9)7-4-2-1-3-5-7;/h1-6H,(H2,10,11);1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C9H8N2S
Molecular Weight 176.238
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Phenthiazamine was developed by Sekizawa et al. as a centrally acting anesthetic for fish. The time required to reduce the positive ganglionic potential in the sympathetic ganglion by phenthiazamine was prolonged in the presence of higher concentrations of Ca2+. The Ca2+-dependent action potential of guinea-pig ureter was reduced by this compound, whereas it did not affect the Na+-dependent action potential.

CNS Activity

Curator's Comment: CNS active in fish and frog

Originator

Curator's Comment: Phenthiazamine was developed by Sekizawa et al. as a centrally acting anesthetic for fish.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Complexes of ruthenium(III) with some 2-aminothiazole derivatives/synthesis, properties and pharmacological studies.
2004
Synthesis, anti-inflammatory and analgesic activities evaluation of some mono, bi and tricyclic pyrimidine derivatives.
2005 Nov 15
Synthesis of a novel bistriazene reagent 4,4'-bis[3-(4-phenylthiazol-2-yl)triazenyl]biphenyl and its highly sensitive color reaction with mercury(II).
2007 Apr 30
5-Methyl-2-[3-(4-phenylthiazol-2-yl)triazenyl]benzenesulfonic acid as a chromogenic reagent of N-cetylpyridinium chloride Synthesis, mechanism and analytical application.
2008 Jan 15
Synthesis and Antibacterial Assessment of N-[4-(4-substituted phenyl)-1,3-thiazol-2-yl]-1,3,5-triazin-2-amine.
2009 Jan
4-Hex-yloxy-3-methoxy-benzaldehyde.
2009 May 14
Synthesis, physico-chemical investigations of Co(II), Ni(II) and Cu(II) complexes and their in vitro microbial, cytotoxic, DNA cleavage studies.
2010 Jun
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Increase in the amplitude of the slow P potential was found in all the specimens of Frog sympathetic ganglion with Phenthiazamine at 0.5 mM
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:36:04 GMT 2023
Edited
by admin
on Sat Dec 16 01:36:04 GMT 2023
Record UNII
C21J96I9HL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
2-AMINO-4-PHENYLTHIAZOLE MONOHYDROCHLORIDE
Systematic Name English
THIAZOLE, 2-AMINO-4-PHENYL-, MONOHYDROCHLORIDE
Common Name English
2-THIAZOLAMINE, 4-PHENYL-, MONOHYDROCHLORIDE
Common Name English
4-PHENYL-2-THIAZOLAMINE HYDROCHLORIDE
Systematic Name English
2-AMINO-4-PHENYLTHIAZOLE HYDROCHLORIDE
Systematic Name English
2-AMINO-4-PHENYL THIAZOLE MONOHYDROCHLORIDE
Systematic Name English
2-THIAZOLAMINE, 4-PHENYL-, HYDROCHLORIDE (1:1)
Systematic Name English
THIAZOLE, 2-AMINO-4-PHENYL-, HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
PUBCHEM
80338
Created by admin on Sat Dec 16 01:36:04 GMT 2023 , Edited by admin on Sat Dec 16 01:36:04 GMT 2023
PRIMARY
CAS
6208-08-8
Created by admin on Sat Dec 16 01:36:04 GMT 2023 , Edited by admin on Sat Dec 16 01:36:04 GMT 2023
PRIMARY
FDA UNII
C21J96I9HL
Created by admin on Sat Dec 16 01:36:04 GMT 2023 , Edited by admin on Sat Dec 16 01:36:04 GMT 2023
PRIMARY
EPA CompTox
DTXSID60977668
Created by admin on Sat Dec 16 01:36:04 GMT 2023 , Edited by admin on Sat Dec 16 01:36:04 GMT 2023
PRIMARY