DMDM HYDANTOIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H12N2O4
Molecular Weight	188.1812
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)N(CO)C(=O)N(CO)C1=O

InChI

InChIKey=WSDISUOETYTPRL-UHFFFAOYSA-N

InChI=1S/C7H12N2O4/c1-7(2)5(12)8(3-10)6(13)9(7)4-11/h10-11H,3-4H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C7H12N2O4
Molecular Weight	188.1812
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30971499 | https://www.ncbi.nlm.nih.gov/pubmed/30145645 | https://www.ncbi.nlm.nih.gov/pubmed/25634979

DMDM hydantoin is a preservative in cosmetics and personal care products. It works by slowing and preventing spoilage in products such as shampoos and hair conditioners, and in skin care products like moisturizers and makeup foundations. DMDM hydantoin is also an antimicrobial agent used in cosmetics and personal care products. As an antimicrobial, it can help prevent the growth of fungi, yeast and harmful bacteria that can make people sick or give them rashes, for example. DMDM hydantoin is a “formaldehyde donor,” which means that to work as a preservative and antimicrobial, it releases small levels of formaldehyde throughout the shelf-life of a personal care product or cosmetic product.

Approval Year

PubMed

Title	Date	PubMed
Preservatives in cosmetics: reactivity of allergenic formaldehyde-releasers towards amino acids through breakdown products other than formaldehyde.	2010-10	20731691
Temporal trends of preservative allergy in Denmark (1985-2008).	2010-02	20136893
Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde.	2010-01	20136876
Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics.	2010-01	20136875
Antimicrobial activity of lavender, tea tree and lemon oils in cosmetic preservative systems.	2009-12-01	19508298
Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: a retrospective analysis from the North American Contact Dermatitis Group.	2007-09	17725923
Pesticide detoxifying functions of N-halamine fabrics.	2006-11	16568365
[Contact allergy to preservatives contained in cosmetics].	2006	17125030
Contact sensitivity to preservatives in Turkey.	2005-06	15932584
Contact allergy from DMDM hydantoin, 1994-2000.	2002-07	12225423

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:45:59 GMT 2025` Edited by `admin` on `Mon Mar 31 17:45:59 GMT 2025`
Record UNII	BYR0546TOW
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DMDM HYDANTOIN

Official Name

English

1,3-DIMETHYLOL-5,5-DIMETHYLHYDANTOIN

Preferred Name

English

1,3 BIS(HYDROXYMETHYL)-5,5- DIMETHYLHYDANTOINDIMETHYLHYDANTOIN

Systematic Name

English

1,3-DIMETHYLOL-5,5-DIMETHYLHYDANTOIN [HSDB]

Common Name

English

1,3-BIS(HYDROXYMETHYL)-5,5-DIMETHYL-2,4-IMIDAZOLIDINEDIONE

Systematic Name

English

1,3-DIMETHYLOL-5,5-DIMETHYL-HYDANTOIN

Systematic Name

English

DMDM HYDANTOIN [II]

Common Name

English

1,3-BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOIN

Systematic Name

English

GLYDANT

Brand Name

English

DMDM HYDANTION [VANDF]

Common Name

English

DMDM HYDANTOIN [VANDF]

Common Name

English

DIMETHYLOL-5,5-DIMETHYLHYDANTOIN

Systematic Name

English

Classification Tree Code System Code

Food Contact Sustance Notif, (FCN No.)

FCN NO. 221