U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C7H12N2O4
Molecular Weight 188.1812
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DMDM HYDANTOIN

SMILES

CC1(C)N(CO)C(=O)N(CO)C1=O

InChI

InChIKey=WSDISUOETYTPRL-UHFFFAOYSA-N
InChI=1S/C7H12N2O4/c1-7(2)5(12)8(3-10)6(13)9(7)4-11/h10-11H,3-4H2,1-2H3

HIDE SMILES / InChI
Molecular Formula C7H12N2O4
Molecular Weight 188.1812
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

DMDM hydantoin is a preservative in cosmetics and personal care products. It works by slowing and preventing spoilage in products such as shampoos and hair conditioners, and in skin care products like moisturizers and makeup foundations. DMDM hydantoin is also an antimicrobial agent used in cosmetics and personal care products. As an antimicrobial, it can help prevent the growth of fungi, yeast and harmful bacteria that can make people sick or give them rashes, for example. DMDM hydantoin is a “formaldehyde donor,” which means that to work as a preservative and antimicrobial, it releases small levels of formaldehyde throughout the shelf-life of a personal care product or cosmetic product.

Approval Year

1952
115
PubMed

PubMed

TitleDatePubMed
Contact allergy from DMDM hydantoin, 1994-2000.
2002 Jul
Contact sensitivity to preservatives in Turkey.
2005 Jun
[Contact allergy to preservatives contained in cosmetics].
2006
Pesticide detoxifying functions of N-halamine fabrics.
2006 Nov
Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: a retrospective analysis from the North American Contact Dermatitis Group.
2007 Sep
Antimicrobial activity of lavender, tea tree and lemon oils in cosmetic preservative systems.
2009 Dec 1
Temporal trends of preservative allergy in Denmark (1985-2008).
2010 Feb
Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde.
2010 Jan
Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics.
2010 Jan
Preservatives in cosmetics: reactivity of allergenic formaldehyde-releasers towards amino acids through breakdown products other than formaldehyde.
2010 Oct
Patents

Patents

JPH04360873A
1
JPH1171210A
1
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:05:17 UTC 2023
Edited
by admin
on Fri Dec 15 15:05:17 UTC 2023
Record UNII
BYR0546TOW
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DMDM HYDANTOIN
II   INCI   VANDF  
INCI  
Official Name English
1,3 BIS(HYDROXYMETHYL)-5,5- DIMETHYLHYDANTOINDIMETHYLHYDANTOIN
Systematic Name English
1,3-DIMETHYLOL-5,5-DIMETHYLHYDANTOIN [HSDB]
Common Name English
1,3-BIS(HYDROXYMETHYL)-5,5-DIMETHYL-2,4-IMIDAZOLIDINEDIONE
Systematic Name English
1,3-DIMETHYLOL-5,5-DIMETHYL-HYDANTOIN
Systematic Name English
DMDM HYDANTOIN [II]
Common Name English
1,3-BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOIN
Systematic Name English
GLYDANT
Brand Name English
DMDM HYDANTION [VANDF]
Common Name English
DMDM HYDANTOIN [INCI]
Common Name English
DMDM HYDANTOIN [VANDF]
Common Name English
DIMETHYLOL-5,5-DIMETHYLHYDANTOIN
Systematic Name English
1,3-DIMETHYLOL-5,5-DIMETHYLHYDANTOIN
HSDB  
Systematic Name English
Classification Tree Code System Code
Food Contact Sustance Notif, (FCN No.) FCN NO. 221
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 104
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 168
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
NCI_THESAURUS C78284
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
EPA PESTICIDE CODE 115501
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
Food Contact Sustance Notif, (FCN No.) FCN NO. 99
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
Code System Code Type Description
EVMPD
SUB32587
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
HSDB
7488
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
WIKIPEDIA
DMDM HYDANTOIN
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
PUBCHEM
22947
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
RXCUI
1310543
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY RxNorm
MESH
C056057
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
CAS
6440-58-0
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
ECHA (EC/EINECS)
229-222-8
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
EPA CompTox
DTXSID8035217
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
NCI_THESAURUS
C77541
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
FDA UNII
BYR0546TOW
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
SMS_ID
100000126159
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
DAILYMED
BYR0546TOW
Created by admin on Fri Dec 15 15:05:17 UTC 2023 , Edited by admin on Fri Dec 15 15:05:17 UTC 2023
PRIMARY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966