PHENOCOLL HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14N2O2.ClH
Molecular Weight	230.691
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCOC1=CC=C(NC(=O)CN)C=C1

InChI

InChIKey=MWMQWESYXCGLFW-UHFFFAOYSA-N

InChI=1S/C10H14N2O2.ClH/c1-2-14-9-5-3-8(4-6-9)12-10(13)7-11;/h3-6H,2,7,11H2,1H3,(H,12,13);1H

HIDE SMILES / InChI

Molecular Formula	C10H14N2O2
Molecular Weight	194.2304
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18734338

Phenocoll is an antineuralgic, analgesic and antipyretic drug. It is a derivative of phenacetin and thus has the same mechanism of action (COX-2 inhibition). Hydrochloride and salicylate salts of phenocoll were used to control inflammation in such diseases as gout, influenza, malaria, rheumatism and pleuritis. The drug is no longer available for marketing.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Prostaglandin G/H synthase 2 48 Target ID: P35354 Gene ID: 5743.0 Gene Symbol: PTGS2 Target Organism: Homo sapiens (Human) Sources: http://www.google.com/patents/US8236355	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Gout 28 Sources: http://journals.lww.com/jonmd/Citation/1892/02000/Phenocoll_Hydrochlorate.4.aspx	Palliative	Approved 8429	Unknown Approved Use Unknown
Rheumatism 10 Sources: http://journals.lww.com/jonmd/Citation/1892/02000/Phenocoll_Hydrochlorate.4.aspx	Palliative	Approved 8429	Unknown Approved Use Unknown
Influenza virus infections 33 Sources: http://journals.lww.com/jonmd/Citation/1892/02000/Phenocoll_Hydrochlorate.4.aspx	Palliative	Approved 8429	Unknown Approved Use Unknown
Malaria 95 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18734338	Palliative	Approved 8429	Unknown Approved Use Unknown
Chorea 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18734338	Palliative	Approved 8429	Unknown Approved Use Unknown
Pleuritis 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18734338	Palliative	Approved 8429	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
NEW AND NON-OFFICIAL REMEDIES.	1908 Apr	18734338

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose is 0.3 to 1.3 g, taken orally (dissolved in water before taking).

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 03:24:18 GMT 2023` Edited by `admin` on `Sat Dec 16 03:24:18 GMT 2023`
Record UNII	BY1A6N7YI0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENOCOLL HYDROCHLORIDE

Common Name

English

ACETAMIDE, 2-AMINO-N-(4-ETHOXYPHENYL)-, MONOHYDROCHLORIDE

Common Name

English

P-ACETOPHENETIDIDE, 2-AMINO-, MONOHYDROCHLORIDE

Common Name

English

ACETAMIDE, 2-AMINO-N-(4-ETHOXYPHENYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

GLYCOCOLL-P-PHENETIDINE HYDROCHLORIDE

Common Name

English

PHENOCOLL HYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID60202164