SODIUM BISULFATE

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Na.HO4S
Molecular Weight	120.06
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].OS([O-])(=O)=O

InChI

InChIKey=WBHQBSYUUJJSRZ-UHFFFAOYSA-M

InChI=1S/Na.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	HO4S
Molecular Weight	97.071
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022372s004lbledt.pdf | https://www.webmd.com/drugs/2/drug-154631/suprep-bowel-prep-kit-oral/details

SULFATE (as sodium sulfate, potassium sulfate, and magnesium sulfate) is a component of SUPREP Bowel Prep Kit. It is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Sulfate salts provide sulfate anions, which are poorly absorbed. The osmotic effect of unabsorbed sulfate anions and the associated cations causes water to be retained within the gastrointestinal tract. SUPREP Bowel Prep Kit, when ingested with a large volume of water, produces copious watery diarrhea.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bowel Cleanser 8 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022372s004lbledt.pdf	Palliative		Approved 8583	SUPREP Bowel Prep Kit Approved Use SUPREP Bowel Prep Kit is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Launch Date 2010

PubMed

Title	Date	PubMed
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.	2014-04	23432541
Evaluation of formocresol versus ferric sulphate primary molar pulpotomy: a systematic review and meta-analysis.	2007-10	17714467
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.	2007-07-18	17636771
Heparan sulphate proteoglycans fine-tune mammalian physiology.	2007-04-26	17460664
Overcoming chondroitin sulphate proteoglycan inhibition of axon growth in the injured brain: lessons from chondroitinase ABC.	2007	17692016
[Therapy of osteoarthritis crystalline glucosamine sulphate/a review of the clinical effcacy].	2007	17515291
Chondroitin sulphate: antioxidant properties and beneficial effects.	2006-12	17168807
Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.	2006-10	16985189
The role of heparan sulphate in inflammation.	2006-09	16917509
Interferon and heparan sulphate.	2006-06	16709188
Heparin/heparan sulphate binding in the TGF-beta cytokine superfamily.	2006-06	16709187
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.	2006-06	16709185
The role of heparan sulphate proteoglycans in angiogenesis.	2006-06	16709184
Insights into the role of heparan sulphate in fibroblast growth factor signalling.	2006-06	16709182
Multiprotein signalling complexes: regional assembly on heparan sulphate.	2006-06	16709181
Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors.	2006-06	16709175
Heparan sulphate proteoglycans and viral vectors : ally or foe?	2006-02	16475944
[Magnesium sulphate for the management of preeclampsia].	2006-01	16406662
Heparan sulphate proteoglycans: the sweet side of development.	2005-07	16072037
A review of the role for magnesium sulphate in preterm labour.	2005-03	15715602
Evidence and practice: the magnesium sulphate story.	2005-02	15749066
A meta-analysis on intravenous magnesium sulphate for treating acute asthma.	2005-01	15613519
Biotechnological engineering of heparin/heparan sulphate: a novel area of multi-target drug discovery.	2005	16026302
Epidemiology of 377 patients with chemical burns in Guangdong province.	2004-09	15302423
Characterization of the Herpesvirus saimiri Orf51 protein.	2004-08-15	15262496
Molecular recognition by LARGE is essential for expression of functional dystroglycan.	2004-06-25	15210115
[The extracellular matrix of the central nervous system: chondroitin sulphate type proteoglycans and neural repair].	2004-05-21	15152354
The SLC13 gene family of sodium sulphate/carboxylate cotransporters.	2004-02	12915942
Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?	2004-01	14690476
Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies.	2003-10	14609305
Dermatan sulphate as an antithrombotic drug.	2003-09-19	13679662
Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders.	2003-08	12878436
Magnesium sulphate versus phenytoin for eclampsia.	2003	14583911
Magnesium sulphate versus diazepam for eclampsia.	2003	14583910
Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.	2003	12804383
Structure-activity relationship of heparan sulphate.	1997-11	9449976
Heparan sulphate proteoglycan and wound healing in skin.	1997-11	9422978
Heparan sulphate.	1997-05	9251237
Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease.	1996-09	8943798
The osmotic and intrinsic mechanisms of the pharmacological laxative action of oral high doses of magnesium sulphate. Importance of the release of digestive polypeptides and nitric oxide.	1996-06	8878010
The role of stromal cell heparan sulphate in regulating haemopoiesis.	1996-05	9172804
Two selectins converge on sulphate. Leukocyte adhesion.	1996-03-01	8805242
Renal and small intestinal sodium-dependent symporters of phosphate and sulphate.	1994-11	7823020
Dextran sulphate induces a PKC and actin independent internalisation of CD4.	1994-09	7829123
Keratan sulphate--a 'reserve' polysaccharide?	1994-04	8038262
Death by tanning--a case of fatal basic chromium sulphate poisoning.	1994	8201096
Heparan sulphate in the binding and activation of basic fibroblast growth factor.	1992-12	1472758
Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme.	1992-04	1516727
Sodium dodecyl sulphate electrophoresis of urinary proteins.	1991-09-13	1939488
Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine.	1990	2094230

Patents

Sample Use Guides

In Vivo Use Guide

Split-Dose (2-Day) Regimen: The evening before colonoscopy: dilute one bottle with water to a total volume of 16 oz. (up to the fill line) and drink the entire amount. Drink 32 ounces of water over the next hour. Next morning: repeat both steps using the second bottle. Complete preparation at least 2 hours before colonoscopy or as directed by a physician.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:15:07 GMT 2025` Edited by `admin` on `Mon Mar 31 18:15:07 GMT 2025`
Record UNII	BU8V88OWIQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

E-514(II)

Preferred Name

English

SODIUM BISULFATE

Official Name

English

INS NO.514(II)

Code

English

Sodium sulfate [WHO-DD]

Common Name

English

SODIUM HYDROGEN SULFATE [MART.]

Common Name

English

SODIUM ACID SULFATE

Common Name

English

INS-514(II)

Code

English

SODIUM BISULFATE [FCC]

Common Name

English

NITRE CAKE

Common Name

English

SODIUM BISULFATE [MI]

Common Name

English

SODIUM BISULFATE [II]

Common Name

English

SODIUM BISULPHATE

Systematic Name

English

NSC-71192

Code

English

Classification Tree Code System Code

JECFA EVALUATION

INS-514(II)