ELQ-300

COC1=C(Cl)C=C2C(=O)C(=C(C)NC2=C1)C3=CC=C(OC4=CC=C(OC(F)(F)F)C=C4)C=C3

InChIKey=WZDNKHCQIZRDKW-UHFFFAOYSA-N

InChI=1S/C24H17ClF3NO4/c1-13-22(23(30)18-11-19(25)21(31-2)12-20(18)29-13)14-3-5-15(6-4-14)32-16-7-9-17(10-8-16)33-24(26,27)28/h3-12H,1-2H3,(H,29,30)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
GO:0005750 \| mitochondrial respiratory chain complex III 1 Target ID: GO:0005750 \| mitochondrial respiratory chain complex III Sources: https://www.ncbi.nlm.nih.gov/pubmed/23515079	Inhibitor 8297		0.58 nM [IC50]

PubMed

Title	Date	PubMed
Quinolone-3-diarylethers: a new class of antimalarial drug.	2013 Mar 20	23515079
ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.	2015 Sep	26124159
Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.	2016 Aug	27270285
Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria.	2017 Oct 13	28927276

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:06:00 GMT 2023` Edited by `admin` on `Sat Dec 16 18:06:00 GMT 2023`
Record UNII	BRC5YE92RX
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

ELQ-300

Code

English

6-CHLORO-7-METHOXY-2-METHYL-3-(4-(4-(TRIFLUOROMETHOXY)PHENOXY)PHENYL)-4(1H)-QUINOLINONE

Systematic Name

English

4(1H)-Quinolinone, 6-chloro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-

Systematic Name

English

Code System Code Type Description

CAS

1354745-52-0