U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Sat Dec 16 14:34:35 GMT 2023
Edited
by admin
on Sat Dec 16 14:34:35 GMT 2023
Source Materials Class ORGANISM
Source Materials Type VIRUS
Source Materials State LIVE GENETICALLY MODIFIED NON-REPLICATING
Source Materials Parent
Organism Family Adenoviridae
Organism Genus Mastadenovirus
Organism Species human mastadenovirus c
Infraspecific Type SEROTYPE
Infraspecific Name TYPE 5
Part WHOLE
Record UNII
BPG11IF0HW
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETBX-051
Common Name English
AN ADENOVIRUS VECTOR CANCER VACCINE COMPOSED OF A REPLICATION-DEFECTIVE, SER OTYPE 5 ADENOVIRUS (AD5) THAT HAS BEEN MODIFIED BY REMOVAL OF THE E1, E2B AND E3 GENES AND INSERTION OF A MODIFIED HUMAN BRACHYURY PROTEIN-EXPRESSING GENE
Common Name English
ADENOVIRAL BRACHYURY VACCINE ETBX-051
Common Name English
Code System Code Type Description
FDA UNII
BPG11IF0HW
Created by admin on Sat Dec 16 14:34:35 GMT 2023 , Edited by admin on Sat Dec 16 14:34:35 GMT 2023
PRIMARY
NCI_THESAURUS
C143034
Created by admin on Sat Dec 16 14:34:35 GMT 2023 , Edited by admin on Sat Dec 16 14:34:35 GMT 2023
PRIMARY
CAS
2171537-82-7
Created by admin on Sat Dec 16 14:34:35 GMT 2023 , Edited by admin on Sat Dec 16 14:34:35 GMT 2023
PRIMARY
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ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN UNKNOWN BRACHYURY PROTEIN EQ43SC3GDB
PROTEIN NOT EXPRESSED (GENE DISRUPTION) viral genes early 1 EARLY E1A PROTEIN (HUMAN ADENOVIRUS 5) MW6YY4WVP4
PROTEIN NOT EXPRESSED (GENE DISRUPTION) viral genes early 2b DNA POLYMERASE (HUMAN ADENOVIRUS 5) ETQ2WKD05X
PROTEIN NOT EXPRESSED (GENE DISRUPTION) viral genes early 2b PRETERMINAL PROTEIN (HUMAN ADENOVIRUS 5) PL0VT48B2N