Felmetatug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:33:50 GMT 2025` Edited by `admin` on `Wed Apr 02 13:33:50 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	BMV2Y9V7RU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Felmetatug

Official Name

English

H-gamma1 heavy chain Homo sapiens (1-450) [VH (Homo sapiens IGHV4-39*01 (96.0%) -(IGHD) -IGHJ5*02 (93.8%), CDR-IMGT [10.7.12] (26-35.53-59.98-109)) (1-120) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (217) (121-218), hinge 1-15

Preferred Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens VTCN1(Vset domain containing T cell activation inhibitor 1, B7 family member H4, B7H4, B7-H4)], Homo sapiens monoclonal antibody;

Common Name

English

felmetatug [INN]

Common Name

English

Immunoglobulin G1, anti-(human/Macaca fascicularis/Mus musculus B7 homolog protein B7H4) (human monoclonal B7H41001 ?1-chain), disulfide with human monoclonal B7H41001 ?-chain, dimer

Common Name

English

Code System Code Type Description

FDA UNII

BMV2Y9V7RU

Created by admin on Wed Apr 02 13:33:50 GMT 2025 , Edited by admin on Wed Apr 02 13:33:50 GMT 2025

PRIMARY

NCI_THESAURUS

C211758

Created by admin on Wed Apr 02 13:33:50 GMT 2025 , Edited by admin on Wed Apr 02 13:33:50 GMT 2025

PRIMARY

INN

13232

Created by admin on Wed Apr 02 13:33:50 GMT 2025 , Edited by admin on Wed Apr 02 13:33:50 GMT 2025

PRIMARY

SMS_ID

300000039889

Created by admin on Wed Apr 02 13:33:50 GMT 2025 , Edited by admin on Wed Apr 02 13:33:50 GMT 2025

PRIMARY

CAS

2924808-29-5

Created by admin on Wed Apr 02 13:33:50 GMT 2025 , Edited by admin on Wed Apr 02 13:33:50 GMT 2025

PRIMARY

From	To
1_22	1_97
2_22	2_97
2_147	2_203
2_223	4_214
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					CSK3SHL2SF

V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1

TARGET->LIGAND

Interaction Type:

PRECLINICAL

Amount:


					VG5Y3A9DFS

Felmetatug Vedotin

CONJUGATE -> PARENT

Amount:

Related Record Type Details


					BMV2Y9V7RU

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS	K		LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL