PEGIPANERMIN

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 08:09:37 GMT 2025` Edited by `admin` on `Wed Apr 02 08:09:37 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	BM6T2K8FIN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

XPRO-1595

Preferred Name

English

PEGIPANERMIN

Official Name

English

PEGIPANERMIN [USAN]

Common Name

English

XPRO1595

Code

English

XENP1595

Code

English

Quellor

Brand Name

English

INB03

Code

English

HOMOSAPIENS TUMOR NECROSIS FACTOR,SOLUBLE FORM (V1>M, R31>C, C69>V, Y87>H, C101>A, A145>R), MONOMER, PEGYLATED ON CYSTEINE 31 : S-((3RS)-(2-((3-(.OMEGA.-METHOXYPOLY(OXYETHANE-1,2-DIYL))PROPYL)CARBAMOYL)ETHYL)-2,5-DIOXOPYRROLIDIN-3-YL)-L-CYSTEINYL

Common Name

English

XENP-1595

Code

English

LIVNate

Brand Name

English

INB-03

Code

English

XPro 1595 [WHO-DD]

Common Name

English

DN-TNF

Common Name

English

SOLUBLE TUMOR NECROSIS FACTOR (1-METHIONINE,31-CYSTEINE,69-VALINE,87-HISTIDINE,101-ALANINE,145-ARGININE) (HUMAN CONSTRUCT XPRO1595), 31-THIOETHER WITH .ALPHA.-(3-((3-(3-MERCAPTO-2,5-DIOXO-1-PYRROLIDINYL)-1-OXOPROPYL)AMINO)PROPYL)-.OMEGA.-METHOXYPOLY(OXY-

Common Name

English

Code System Code Type Description

FDA UNII

BM6T2K8FIN

Created by admin on Wed Apr 02 08:09:37 GMT 2025 , Edited by admin on Wed Apr 02 08:09:37 GMT 2025

PRIMARY

SMS_ID

300000039029

Created by admin on Wed Apr 02 08:09:37 GMT 2025 , Edited by admin on Wed Apr 02 08:09:37 GMT 2025

PRIMARY

CAS

2489785-77-3

Created by admin on Wed Apr 02 08:09:37 GMT 2025 , Edited by admin on Wed Apr 02 08:09:37 GMT 2025

PRIMARY

USAN

JK-114

Created by admin on Wed Apr 02 08:09:37 GMT 2025 , Edited by admin on Wed Apr 02 08:09:37 GMT 2025

PRIMARY

INN

12103

Created by admin on Wed Apr 02 08:09:37 GMT 2025 , Edited by admin on Wed Apr 02 08:09:37 GMT 2025

PRIMARY

NCI_THESAURUS

C183319

Created by admin on Wed Apr 02 08:09:37 GMT 2025 , Edited by admin on Wed Apr 02 08:09:37 GMT 2025

PRIMARY

Related Record Type Details


					MY1WB2JBC0

TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6, SOLUBLE FORM

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					BM6T2K8FIN

ACTIVE MOIETY

Comments:

INB03 acts by a “dominant-negative” mechanism to eliminate pro-inflammatory solTNF homotrimers through exchange of monomeric subunits between the compound and the native cytokine, whereby the native homotrimer becomes an inactive heterotrimer.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_31] [2_31] [3_31]				UNSPECIFIED SUBSTANCE	bc566539 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL