Uprevstobart

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 18:24:15 GMT 2023` Edited by `admin` on `Sat Dec 16 18:24:15 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	BH6FYV3BSC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Uprevstobart

Official Name

English

Immunoglobulin G1 [301-alanine,de-C-terminal-lysine], anti-(human CD73 antigen) (human-Mus musculus monoclonal INCA00186 γ1-chain), disulfide with human-Mus musculus monoclonal INCA00186 κ-chain, dimer

Common Name

English

INCA00186

Code

English

Immunoglobulin G1-kappa, anti-[Homo sapiens NT5E (5'-nucleotidase ecto, 5' nucleotidase, 5'-NT, NT5, CD73)], humanized monoclonal antibody

Common Name

English

uprevstobart [INN]

Common Name

English

INCA-00186

Code

English

Gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV5-51*01 (86.7%) -(IGHD) -IGHJ4*01 (85.7%) Q120>A(113), L123>T (116), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*03, G1m3, nG1m1 CH1R120 CH3 E12, M14, G1v29 CH2 A84.4 (CH1

Common Name

English

Code System Code Type Description

FDA UNII

BH6FYV3BSC

Created by admin on Sat Dec 16 18:24:15 GMT 2023 , Edited by admin on Sat Dec 16 18:24:15 GMT 2023

PRIMARY

CAS

2762201-85-2

Created by admin on Sat Dec 16 18:24:15 GMT 2023 , Edited by admin on Sat Dec 16 18:24:15 GMT 2023

PRIMARY

INN

12670

Created by admin on Sat Dec 16 18:24:15 GMT 2023 , Edited by admin on Sat Dec 16 18:24:15 GMT 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_148	2_204
2_224	4_214
2_265	2_325
1_148	1_204
2_371	2_429
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_224	3_214
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429

Related Record Type Details


					T8635M4C7O

5'-NUCLEOTIDASE

TARGET -> INHIBITOR

Comments:

In vitro and in vivo pharmacology studies show INCA00186 to be a potent binder and inhibitor of CD73 function

Interaction Type:

IN-VITRO, IN-VIVO

Amount:

Related Record Type Details


					BH6FYV3BSC

Uprevstobart

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL
Molecular Formula	CHEMICAL