| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H16ClN3S |
| Molecular Weight | 293.815 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
![Structure of 6-[(4-Chlorophenyl)methyl]-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine](/img/67f60426-118c-4ba0-bb65-6c43b95a1092.svg?size=400&version=5&stereo=false "Structure of 6-[(4-Chlorophenyl)methyl]-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine")
SMILES
NC1=NC2=C(CCN(CC3=CC=C(Cl)C=C3)CC2)S1
InChI
InChIKey=QHNGFZZXGOFXPN-UHFFFAOYSA-N
InChI=1S/C14H16ClN3S/c15-11-3-1-10(2-4-11)9-18-7-5-12-13(6-8-18)19-14(16)17-12/h1-4H,5-9H2,(H2,16,17)
| Molecular Formula | C14H16ClN3S |
| Molecular Weight | 293.815 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
B-HT 958 (2-amino-6-(p-chlorobenzyl)-4H-5,6,7,8-tetrahydrothiazolo[5,4-d]az epine), a compound chemically related to clonidine-like drugs of the azepine type, exerts a strong agonistic effect on brain dopamine autoreceptors. B-HT 958 is a partial agonist at peripheral alpha 2-adrenoceptors. In doses of about 1 mg/kg and with low frequency sympathetic stimulation (less than 6.4 Hz) it acts presynaptically as agonist; in this dose the drug acts postsynaptically mainly as antagonist.
CNS Activity
Originator
Approval Year
PubMed
Sample Use Guides
Rats: B-HT 958 350 mg/kg i.v. caused significant falls in blood pressure and heart rate which were maximal 5 min after dosing
Route of Administration:
Intravenous