Zeldesmeran

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NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 15:45:56 GMT 2025` Edited by `admin` on `Wed Apr 02 15:45:56 GMT 2025`
Nucleic Acid Type	MRNA
Sequence Type	COMPLETE
Record UNII	BD2KE88JH4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Zeldesmeran

Official Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Gm)-capped all uridine?N1-methylpseudouridine-substituted severe acute respiratory syndrome coronavirus 2 spike glycoprotein [614-glycine]-specifying plus 5?- and 3?-untranslated flanking region-containing poly(A)-tai

Preferred Name

English

messenger RNA (mRNA), 5'-capped, encoding a full-length, codon-optimised version of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike (S) glycoprotein (based upon GenBank ID: MT270101.1), containing the D614G mutation, flanked by a 5

Common Name

English

zeldesmeran [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C203100

Created by admin on Wed Apr 02 15:45:56 GMT 2025 , Edited by admin on Wed Apr 02 15:45:56 GMT 2025

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CAS

2726459-47-6

Created by admin on Wed Apr 02 15:45:56 GMT 2025 , Edited by admin on Wed Apr 02 15:45:56 GMT 2025

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SMS_ID

300000051847

Created by admin on Wed Apr 02 15:45:56 GMT 2025 , Edited by admin on Wed Apr 02 15:45:56 GMT 2025

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FDA UNII

BD2KE88JH4

Created by admin on Wed Apr 02 15:45:56 GMT 2025 , Edited by admin on Wed Apr 02 15:45:56 GMT 2025

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INN

12547

Created by admin on Wed Apr 02 15:45:56 GMT 2025 , Edited by admin on Wed Apr 02 15:45:56 GMT 2025

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Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_4238	4238 / 4238

Linkage	Site Range	Site Count
Phosphate	1_2-1_4238	4237 / 4237

Related Record Type Details


					B6L4N5Z4GH

SARS-COV2

TARGET->VACCINE ANTIGEN

Amount:

Related Record Type Details


					BD2KE88JH4

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE INSERTIONS	[1_1]	5'-TERMINUS			5'-GUANOSINE-M-RNA-CAP-1-3'-PHOSPHATE	T0HQY09X7B
NUCLEOSIDE_SUBSTITUTION		RESIDUE_SPECIFIC	U		N1-METHYLPSEUDOURIDINE	09RAD4M6WF