ACECAINIDE HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H23N3O2.ClH
Molecular Weight	313.823
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN(CC)CCNC(=O)C1=CC=C(NC(C)=O)C=C1

InChI

InChIKey=IYEWBJUCJHKLHD-UHFFFAOYSA-N

InChI=1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C15H23N3O2
Molecular Weight	277.362
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1693889 | https://www.ncbi.nlm.nih.gov/pubmed/9730262 | https://www.ncbi.nlm.nih.gov/pubmed/6188570 | https://adisinsight.springer.com/drugs/800000315 | https://www.ncbi.nlm.nih.gov/pubmed/11245854

Acecainide (N-acetylprocainamide), the N-acetylated metabolite of procainamide, is a Class III antiarrhythmic agent. Acecainide exerts cardiac anticholinergic effect. It elicits smooth muscle relaxation mainly through the activation of plasma membrane K+ channels. Acecainide markedly reduced premature ventricular beats and prevented induction of ventricular tachycardia. Acecainide appears to offer advantages over procainamide, particularly with respect to the reduced formation of antinuclear antibodies. Acecainide development has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Potassium channel 4 Target ID: Potassium channel Sources: https://adisinsight.springer.com/drugs/800000315 \| https://www.ncbi.nlm.nih.gov/pubmed/11245854	Antagonist 2778

PubMed

Title	Date	PubMed
N-substituted benzamides inhibit nuclear factor-kappaB and nuclear factor of activated T cells activity while inducing activator protein 1 activity in T lymphocytes.	2001 Aug	11566320
Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.	2008	19040780
Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis.	2008 May	18489081

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:26:42 GMT 2023` Edited by `admin` on `Fri Dec 15 15:26:42 GMT 2023`
Record UNII	B9K738KX14
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACECAINIDE HYDROCHLORIDE

Official Name

English

ASL-601

Code

English

BENZAMIDE, 4-(ACETYLAMINO)-N-(2-(DIETHYLAMINO)ETHYL)-, MONOHYDROCHLORIDE

Common Name

English

ACECAINIDE HYDROCHLORIDE [MI]

Common Name

English

4'-((2-(DIETHYLAMINO)ETHYL)CARBAMOYL)ACETANILIDE MONOHYDROCHLORIDE

Systematic Name

English

ASL 601

Code

English

ACECAINIDE HYDROCHLORIDE [MART.]

Common Name

English

ACECAINIDE HCL

Common Name

English

ACECAINIDE HYDROCHLORIDE [USAN]

Common Name

English

NSC-759312

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C47793