Seniprutug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 18:57:31 GMT 2025` Edited by `admin` on `Wed Apr 02 18:57:31 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	B9DMX93Z6X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G1, anti-(human T cell receptor ? chain variable 9) (human-Rattus norvegicus monoclonal BCD-180 ?1-chain), disulfide with human-Rattus norvegicus monoclonal BCD-180 ?-chain, dimer

Preferred Name

English

Seniprutug

Official Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens TRBV9 (T cell receptor beta locus variable 9 gene)], humanized monoclonal antibody

Common Name

English

gamma1 heavy chain humanized (1-452) [VH (Homo sapiens IGHV7-4-1*02 (87.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.15] (26-33.51-58.97-111)) (1-122) -Homo sapiens IGHG1*03 (100%), G1m3, nG1m1 CH1 R120, E12, M14 (CH1 R120 (219) (123-220), hinge 1-15 (221

Common Name

English

seniprutug [INN]

Common Name

English

Code System Code Type Description

FDA UNII

B9DMX93Z6X

Created by admin on Wed Apr 02 18:57:31 GMT 2025 , Edited by admin on Wed Apr 02 18:57:31 GMT 2025

PRIMARY

INN

12735

Created by admin on Wed Apr 02 18:57:31 GMT 2025 , Edited by admin on Wed Apr 02 18:57:31 GMT 2025

PRIMARY

CAS

2484772-72-5

Created by admin on Wed Apr 02 18:57:31 GMT 2025 , Edited by admin on Wed Apr 02 18:57:31 GMT 2025

PRIMARY

SMS_ID

300000051904

Created by admin on Wed Apr 02 18:57:31 GMT 2025 , Edited by admin on Wed Apr 02 18:57:31 GMT 2025

PRIMARY

NCI_THESAURUS

C203152

Created by admin on Wed Apr 02 18:57:31 GMT 2025 , Edited by admin on Wed Apr 02 18:57:31 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_149	2_205
2_225	4_214
2_266	2_326
1_149	1_205
2_372	2_430
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_225	3_214
1_231	2_231
1_234	2_234
1_266	1_326
1_372	1_430

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_302
N	2_302

Related Record Type Details


					24TBP32H2N

T cell receptor beta variable 9

TARGET->LIGAND

Amount:

Related Record Type Details


					B9DMX93Z6X

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_452] [2_452]	C-TERMINUS	K		LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL