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Details

Stereochemistry ACHIRAL
Molecular Formula C9H15N3.C4H4O4
Molecular Weight 281.3077
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of TETRYDAMINE MALEATE

SMILES

OC(=O)\C=C/C(O)=O.CNC1=C2CCCCC2=NN1C

InChI

InChIKey=WBQNUTJPYOXRCC-BTJKTKAUSA-N
InChI=1S/C9H15N3.C4H4O4/c1-10-9-7-5-3-4-6-8(7)11-12(9)2;5-3(6)1-2-4(7)8/h10H,3-6H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI

Molecular Formula C9H15N3
Molecular Weight 165.2355
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Tetrydamine is a member of the indazol class of non-steroidal anti-inflammatory drugs. It is an analgesic and anti-inflammatory drug. Tetrydamine lavage reduced or eliminated all inflammation symptoms like burning, leucorrhea, etc. and resulted very well tolerated in vulvovaginitis, symptomatic bacterial vaginosis and cervicitis treatment.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Fomene
Palliative
Fomene
Palliative
Fomene
PubMed

PubMed

TitleDatePubMed
[Absorption, metabolism and excretion of 2-methyl-3-methylamino-4,5,6,7-tetrahydroindazole (tetridamine) in the rat].
1972 Nov
[Tetridamine in the therapy of bacterial vaginosis].
1991 May
Activity and tolerability of tetridamine vaginal lavage in rats and women.
1992 Mar
Oral tetridamine exposures.
2009 Feb
Patents

Patents

Sample Use Guides

In Vivo Use Guide
1 or 2 vaginal irrigations daily. The irrigation fluid is prepared by dissolving 500 mg of the powder formulation in one liter of water.
Route of Administration: Vaginal
Substance Class Chemical
Created
by admin
on Tue Oct 22 19:39:17 UTC 2019
Edited
by admin
on Tue Oct 22 19:39:17 UTC 2019
Record UNII
B976EB226W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TETRYDAMINE MALEATE
Common Name English
TETRIDAMINE MALEATE [WHO-DD]
Common Name English
2H-INDAZOL-3-AMINE, 4,5,6,7-TETRAHYDRO-N,2-DIMETHYL-, (2Z)-2-BUTENEDIOATE (1:1)
Systematic Name English
TETRIDAMINE MALEATE
WHO-DD  
Common Name English
Code System Code Type Description
CAS
22911-97-3
Created by admin on Tue Oct 22 19:39:17 UTC 2019 , Edited by admin on Tue Oct 22 19:39:17 UTC 2019
PRIMARY
EVMPD
SUB28844
Created by admin on Tue Oct 22 19:39:17 UTC 2019 , Edited by admin on Tue Oct 22 19:39:17 UTC 2019
PRIMARY
ECHA (EC/EINECS)
245-318-2
Created by admin on Tue Oct 22 19:39:17 UTC 2019 , Edited by admin on Tue Oct 22 19:39:17 UTC 2019
PRIMARY
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PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
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ACTIVE MOIETY