U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C12H2Cl6O2
Molecular Weight 390.861
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN

SMILES

ClC1=CC2=C(OC3=CC(Cl)=C(Cl)C(Cl)=C3O2)C(Cl)=C1Cl

InChI

InChIKey=YCLUIPQDHHPDJJ-UHFFFAOYSA-N
InChI=1S/C12H2Cl6O2/c13-3-1-5-11(9(17)7(3)15)20-6-2-4(14)8(16)10(18)12(6)19-5/h1-2H

HIDE SMILES / InChI

Molecular Formula C12H2Cl6O2
Molecular Weight 390.861
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells.
2015-04-20
Analysis of the CYP1A1 mRNA dose-response in human keratinocytes indicates that relative potencies of dioxins, furans, and PCBs are species and congener specific.
2010-12
An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus.
2010-05-20
Serum concentrations of selected persistent organic pollutants in a sample of pregnant females and changes in their concentrations during gestation.
2009-08
Determination of some congeners of polychlorinated dibenzo-p-dioxins (PCDDs) in milk using gas chromatography.
2009-06
Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population.
2009-04
Association of organochlorine pesticides with peripheral neuropathy in patients with diabetes or impaired fasting glucose.
2008-11
Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.
2008-04
Association of a polychlorinated dibenzo-p-dioxin, a polychlorinated biphenyl, and DDT with diabetes in the 1999-2002 National Health and Nutrition Examination Survey.
2007-03
Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds.
2006-08
Aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) expression in Baikal seal (Pusa sibirica) and association with 2,3,7,8-TCDD toxic equivalents and CYP1 expression levels.
2005-07
Exposures among pregnant women near the World Trade Center site on 11 September 2001.
2005-06
Photodegradation of tetra- and hexachlorodibenzo-p-dioxins.
2005-04-11
Evaluation of serum dioxin congeners among residents near continuously burning municipal solid waste incinerators in Korea.
2005-04
PCDD/F and PCB in harbour seals (Phoca vitulina) from British Columbia: response to exposure to pulp mill effluents.
2005-03
Active elimination of causative PCDFs/DDs congeners of Yusho by one year intake of FBRA in Japanese people.
2003-05
Fecal excretion of dioxin in mice enhanced by intake of dietary fiber bearing chlorophyllin.
2003-02
Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains.
2002-05-15
Relative potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners to induce cytochrome P4501A mRNA in a zebrafish liver cell line.
2001-05
Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: correlation of increased serum PCB levels with endometriosis.
2001-01
Putative link between transcriptional regulation of IgM expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the aryl hydrocarbon receptor/dioxin-responsive enhancer signaling pathway.
2000-11
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:08:12 GMT 2025
Edited
by admin
on Mon Mar 31 19:08:12 GMT 2025
Record UNII
B94L7A4G3D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN
HSDB  
Common Name English
1,2,3,6,7,8-HEXACHLORODIBENZO-P-DIOXIN [HSDB]
Preferred Name English
PCDD 67
Common Name English
DIBENZO(B,E)(1,4)DIOXIN, 1,2,3,6,7,8-HEXACHLORO-
Systematic Name English
1,2,3,6,7,8-HEXACHLORODIBENZODIOXIN
Systematic Name English
1,2,3,6,7,8-HXCDD
Common Name English
HEXACHLORODIBENZO-P-DIOXIN, 1,2,3,6,7,8-
Common Name English
Code System Code Type Description
HSDB
4154
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
MESH
C046838
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
CAS
57653-85-7
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
PUBCHEM
42540
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
FDA UNII
B94L7A4G3D
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY
EPA CompTox
DTXSID0023824
Created by admin on Mon Mar 31 19:08:12 GMT 2025 , Edited by admin on Mon Mar 31 19:08:12 GMT 2025
PRIMARY