ZD-2138

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H24FNO4
Molecular Weight	397.4394
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1(CCOCC1)C2=CC(F)=CC(OCC3=CC4=C(C=C3)N(C)C(=O)C=C4)=C2

InChI

InChIKey=SLZBEPLWGGRZAY-UHFFFAOYSA-N

InChI=1S/C23H24FNO4/c1-25-21-5-3-16(11-17(21)4-6-22(25)26)15-29-20-13-18(12-19(24)14-20)23(27-2)7-9-28-10-8-23/h3-6,11-14H,7-10,15H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C23H24FNO4
Molecular Weight	397.4394
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Induction of hepatic microsomal drug-metabolizing enzymes by inhibitors of 5-lipoxygenase (5-LO): studies in rats and 5-LO knockout mice.	2001-09	11509739
Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway.	1998-05	9580604
Characterization of the arachidonate and ATP binding sites of human 5-lipoxygenase using photoaffinity labeling and enzyme immobilization.	1995-10-17	7577949
The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses.	1994-05-23	7522174
Calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis: a rapid method to evaluate inhibitors of arachidonic acid metabolism in vivo.	1993	18475545

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:07:07 GMT 2025` Edited by `admin` on `Mon Mar 31 18:07:07 GMT 2025`
Record UNII	B6G6OX1ZH5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZD-2138

Code

English

ICI-D-2138

Preferred Name

English

2(1H)-QUINOLINONE, 6-((3-FLUORO-5-(TETRAHYDRO-4-METHOXY-2H-PYRAN-4-YL)PHENOXY)METHYL)-1-METHYL-

Systematic Name

English

6-((3-FLUORO-5-(TETRAHYDRO-4-METHOXY-2H-PYRAN-4-YL)PHENOXY)METHYL)-1-METHYL-2(1H)-QUINOLINONE

Systematic Name

English

Code System Code Type Description

CAS

140841-32-3

Created by admin on Mon Mar 31 18:07:07 GMT 2025 , Edited by admin on Mon Mar 31 18:07:07 GMT 2025

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EPA CompTox

DTXSID90161477

Created by admin on Mon Mar 31 18:07:07 GMT 2025 , Edited by admin on Mon Mar 31 18:07:07 GMT 2025

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FDA UNII

B6G6OX1ZH5

Created by admin on Mon Mar 31 18:07:07 GMT 2025 , Edited by admin on Mon Mar 31 18:07:07 GMT 2025

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PUBCHEM

132306

Created by admin on Mon Mar 31 18:07:07 GMT 2025 , Edited by admin on Mon Mar 31 18:07:07 GMT 2025

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