ISAGLIDOLE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H13FN4
Molecular Weight	220.2461
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ISAGLIDOLE

Structure Search

SMILES

FC1=C2CN(CC2=CC=C1)NC3=NCCN3

InChI

InChIKey=ZLVARELBORDLAV-UHFFFAOYSA-N

InChI=1S/C11H13FN4/c12-10-3-1-2-8-6-16(7-9(8)10)15-11-13-4-5-14-11/h1-3H,4-7H2,(H2,13,14,15)

HIDE SMILES / InChI

Molecular Formula	C11H13FN4
Molecular Weight	220.2461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2572976 | https://www.ncbi.nlm.nih.gov/pubmed/1356563

ISAGLIDOLE, an imidazoline derivative, is an alpha2-adrenoceptor antagonist. It stimulates insulin release in animal studies.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Investigations of the subtype of alpha 2-adrenoceptor mediating contractions of the human saphenous vein.	1992-06	1356563
Investigations of prejunctional alpha 2-adrenoceptors in rat atrium, vas deferens and submandibular gland.	1992-02-11	1351849
Effect of a new alpha 2-adrenoceptor antagonist on poststenotic coronary resistance and myocardial function.	1990-08	1978679
An insulin-releasing property of imidazoline derivatives is not limited to compounds that block alpha-adrenoceptors.	1989-09	2572976

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:27:59 GMT 2025` Edited by `admin` on `Mon Mar 31 18:27:59 GMT 2025`
Record UNII	B51UC955KQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISAGLIDOLE

Official Name

English

isaglidole [INN]

Preferred Name

English

4-FLUORO-2-(2-IMIDAZOLIN-2-YLAMINO)ISOINDOLINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C72900

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

Code System Code Type Description

PUBCHEM

183683

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

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EPA CompTox

DTXSID60149323

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

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SMS_ID

100000083377

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

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CAS

110605-64-6

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

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INN

6440

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

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FDA UNII

B51UC955KQ

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

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ChEMBL

CHEMBL2105108

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

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EVMPD

SUB08301MIG

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

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NCI_THESAURUS

C65966

Created by admin on Mon Mar 31 18:27:59 GMT 2025 , Edited by admin on Mon Mar 31 18:27:59 GMT 2025

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