Danvilostomig

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 15:39:00 GMT 2025` Edited by `admin` on `Wed Apr 02 15:39:00 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	B4Q67YX49Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G1 [235-alanine,236-alanine,238-alanine,322-alanine,de-448-lysine], bispecific, anti-(human cytotoxic T-lymphocyte-associated protein 4) (human monoclonal MDX010 ?1-chain) fusion protein with peptide linker (GGGGS)2 fusion protein with imm

Preferred Name

English

Danvilostomig

Official Name

English

immunoglobulin G1-kappa_scFv, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte-associated antigen 4, cytotoxic T-lymphocyte-associated protein 4, CTLA-4, CD152)], each heavy chain being fused to a scFv anti-[Homo sapiens PDCD1 (programmed cell death 1, P

Common Name

English

danvilostomig [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C178449

Created by admin on Wed Apr 02 15:39:00 GMT 2025 , Edited by admin on Wed Apr 02 15:39:00 GMT 2025

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FDA UNII

B4Q67YX49Q

Created by admin on Wed Apr 02 15:39:00 GMT 2025 , Edited by admin on Wed Apr 02 15:39:00 GMT 2025

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INN

12198

Created by admin on Wed Apr 02 15:39:00 GMT 2025 , Edited by admin on Wed Apr 02 15:39:00 GMT 2025

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CAS

2599198-80-6

Created by admin on Wed Apr 02 15:39:00 GMT 2025 , Edited by admin on Wed Apr 02 15:39:00 GMT 2025

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SMS_ID

300000051272

Created by admin on Wed Apr 02 15:39:00 GMT 2025 , Edited by admin on Wed Apr 02 15:39:00 GMT 2025

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From	To
4_135	4_195
4_23	4_89
3_135	3_195
3_23	3_89
2_615	2_680
2_479	2_552
2_368	2_426
2_262	2_322
2_221	4_215
2_145	2_201
2_22	2_96
1_615	1_680
1_479	1_552
1_368	1_426
1_262	1_322
1_230	2_230
1_227	2_227
1_221	3_215
1_145	1_201
1_22	1_96

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					938DNF64FO

PROGRAMMED CELL DEATH PROTEIN 1

TARGET->LIGAND

Amount:


					KYU4T5WAI2

CYTOTOXIC T-LYMPHOCYTE PROTEIN 4

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					B4Q67YX49Q

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL