Eglatoprutug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 05:41:46 GMT 2025` Edited by `admin` on `Wed Apr 02 05:41:46 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	Humanized
Sequence Type	COMPLETE
Record UNII	B4IT1FAK55
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G1 [de-447-lysine], anti-(human c-Kit protein) (human-Mus musculus monoclonal HF12 10-9B8 ?1-chain), disulfide with human-Mus musculus monoclonal HF12 10-9B8 ?-chain, dimer

Preferred Name

English

Eglatoprutug

Official Name

English

eglatoprutug [INN]

Common Name

English

Code System Code Type Description

CAS

2518200-21-8

Created by admin on Wed Apr 02 05:41:46 GMT 2025 , Edited by admin on Wed Apr 02 05:41:46 GMT 2025

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NCI_THESAURUS

C203151

Created by admin on Wed Apr 02 05:41:46 GMT 2025 , Edited by admin on Wed Apr 02 05:41:46 GMT 2025

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SMS_ID

300000046879

Created by admin on Wed Apr 02 05:41:46 GMT 2025 , Edited by admin on Wed Apr 02 05:41:46 GMT 2025

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INN

12165

Created by admin on Wed Apr 02 05:41:46 GMT 2025 , Edited by admin on Wed Apr 02 05:41:46 GMT 2025

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FDA UNII

B4IT1FAK55

Created by admin on Wed Apr 02 05:41:46 GMT 2025 , Edited by admin on Wed Apr 02 05:41:46 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_144	2_200
2_220	4_218
2_261	2_321
1_144	1_200
2_367	2_425
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198
1_220	3_218
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					B4IT1FAK55

ACTIVE MOIETY

Comments:

Has low potential to amplify IgE-Fc?RI-mediated degranulation; FSI-174 in combination with the anti-CD47 antibody magrolimab is effective in depleting HSCs as measured by bone marrow biopsies.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL