MANGANESE GLYCINATE is composed of trace mineral manganese and an amino acid, glycine. It is easily absorbable. It helps the body in a variety of ways including formation of clotting factors, connective tissue sex hormones and bones. It helps in the absorption of calcium and metabolism of carbohydrate as well as fat. It plays an important role for normal nerve and brain function. Moreover, it is a component of the enzyme, superoxide dismutase which helps fighting free radicals. Decreased manganese level can cause infertility, seizures, weakness and bone malformation. Manganese Glycinate (Mn(glycinate)2) has application as a contrast enhancement agent for magnetic resonance imaging in the heart. Toxicity, which is primarily due to the action of manganese as a calcium channel blocker with effects on muscle electrophysiology and contractility, has limited the use of manganese salts as paramagnetic contrast agents. Mn(glycinate)2 exerts its negative inotropic effect, at least partially, by interfering with the function of the L-type Ca channels at high concentrations.