Details
Stereochemistry | ACHIRAL |
Molecular Formula | C27H38N2 |
Molecular Weight | 390.604 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCC\N=C\N1CCC(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3
InChI
InChIKey=JXPCRJDMUSNASY-WEMUOSSPSA-N
InChI=1S/C27H38N2/c1-2-3-4-5-6-13-20-28-23-29-21-18-26(19-22-29)27(24-14-9-7-10-15-24)25-16-11-8-12-17-25/h7-12,14-17,23,26-27H,2-6,13,18-22H2,1H3/b28-23+
Molecular Formula | C27H38N2 |
Molecular Weight | 390.604 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Optical Activity | NONE |
Fenoctimine is a nonanticholinergic inhibitor of gastric acid secretion in dogs and rats. Fenoctimine was more potent than cimetidine in the reduction of basal acid secretion in the gastric fistula rat and inhibited the production of gastric acid stimulated by histamine, gastrin tetrapeptide or bethanechol in the chronic gastric fistula dog. This compound is not an H2-antagonist but does inhibit the H+/K+-ATPase of hog gastric mucosa. The in vitro metabolism of fenoctimine by rat liver homogenates resulted in the oxidation of the aliphatic chain at the seven carbon, initially to an alcohol and then to a ketone. The unexpectedly weak effect of fenoctimine as a gastric antisecretory agent in humans, as well as anticholinergic effects, may be due to its extensive metabolism, which is different from that seen in dog and rat. The development of fenoctimine has been discontinued for unspecified reason.
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:20:54 GMT 2023
by
admin
on
Fri Dec 15 17:20:54 GMT 2023
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Record UNII |
B45CF873F8
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Record Status |
Validated (UNII)
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Record Version |
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-
Download
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Common Name | English |
Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29701
Created by
admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
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Code System | Code | Type | Description | ||
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C76485
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4790
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B45CF873F8
Created by
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50455
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C037813
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100000081300
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SUB07575MIG
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69365-65-7
Created by
admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
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DTXSID30867820
Created by
admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
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CHEMBL150283
Created by
admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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ACTIVE MOIETY |