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Details

Stereochemistry ACHIRAL
Molecular Formula C27H38N2
Molecular Weight 390.604
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FENOCTIMINE

SMILES

CCCCCCCC\N=C\N1CCC(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=JXPCRJDMUSNASY-WEMUOSSPSA-N
InChI=1S/C27H38N2/c1-2-3-4-5-6-13-20-28-23-29-21-18-26(19-22-29)27(24-14-9-7-10-15-24)25-16-11-8-12-17-25/h7-12,14-17,23,26-27H,2-6,13,18-22H2,1H3/b28-23+

HIDE SMILES / InChI

Molecular Formula C27H38N2
Molecular Weight 390.604
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Fenoctimine is a nonanticholinergic inhibitor of gastric acid secretion in dogs and rats. Fenoctimine was more potent than cimetidine in the reduction of basal acid secretion in the gastric fistula rat and inhibited the production of gastric acid stimulated by histamine, gastrin tetrapeptide or bethanechol in the chronic gastric fistula dog. This compound is not an H2-antagonist but does inhibit the H+/K+-ATPase of hog gastric mucosa. The in vitro metabolism of fenoctimine by rat liver homogenates resulted in the oxidation of the aliphatic chain at the seven carbon, initially to an alcohol and then to a ketone. The unexpectedly weak effect of fenoctimine as a gastric antisecretory agent in humans, as well as anticholinergic effects, may be due to its extensive metabolism, which is different from that seen in dog and rat. The development of fenoctimine has been discontinued for unspecified reason.

Approval Year

Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 17:20:54 GMT 2023
Edited
by admin
on Fri Dec 15 17:20:54 GMT 2023
Record UNII
B45CF873F8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FENOCTIMINE
INN  
INN  
Official Name English
PIPERIDINE, 4-(DIPHENYLMETHYL)-1-((OCTYLIMINO)METHYL)-, HEMIHYDRATE
Common Name English
4-(DIPHENYLMETHYL)-1-(N-OCTYLFORMIMIDOYL)PIPERIDINE, HEMIHYDRATE
Common Name English
fenoctimine [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29701
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C76485
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
INN
4790
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
FDA UNII
B45CF873F8
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
PUBCHEM
50455
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
MESH
C037813
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
SMS_ID
100000081300
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
EVMPD
SUB07575MIG
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
CAS
69365-65-7
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
EPA CompTox
DTXSID30867820
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
ChEMBL
CHEMBL150283
Created by admin on Fri Dec 15 17:20:55 GMT 2023 , Edited by admin on Fri Dec 15 17:20:55 GMT 2023
PRIMARY
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SALT/SOLVATE -> PARENT
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ACTIVE MOIETY