Comekibart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 18:10:06 GMT 2025` Edited by `admin` on `Wed Apr 02 18:10:06 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	B343W7ZE23
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MG-K10

Preferred Name

English

Comekibart

Official Name

English

comekibart [INN]

Common Name

English

MGK-10

Code

English

MGK10

Code

English

immunoglobulin G4-kappa, anti-[Homo sapiens IL4R (interleukin 4 receptor, IL4RA, IL-4RA, interleukin 13 receptor, CD124)], humanized monoclonal antibody; H-gamma4 heavy chain humanized (1-448) [VH (Homo sapiens IGHV3-48*01 (93.9%) -(IGHD) -IGHJ4*01 (100%

Common Name

English

Immunoglobulin G4, [222-proline,428-leucine,435-serine,de-C-terminal-lysine], anti-(human interleukin 4 receptor ?) (human-Mus musculus monoclonal MG-K10 ?4-chain), disulfide with human-Mus musculus monoclonal MG-K10 ?-chain, dimer

Common Name

English

Code System Code Type Description

INN

12879

Created by admin on Wed Apr 02 18:10:06 GMT 2025 , Edited by admin on Wed Apr 02 18:10:06 GMT 2025

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CAS

2833673-47-3

Created by admin on Wed Apr 02 18:10:06 GMT 2025 , Edited by admin on Wed Apr 02 18:10:06 GMT 2025

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NCI_THESAURUS

C206895

Created by admin on Wed Apr 02 18:10:06 GMT 2025 , Edited by admin on Wed Apr 02 18:10:06 GMT 2025

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FDA UNII

B343W7ZE23

Created by admin on Wed Apr 02 18:10:06 GMT 2025 , Edited by admin on Wed Apr 02 18:10:06 GMT 2025

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SMS_ID

300000054774

Created by admin on Wed Apr 02 18:10:06 GMT 2025 , Edited by admin on Wed Apr 02 18:10:06 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_136	4_214
2_149	2_205
2_263	2_323
1_136	3_214
2_369	2_427
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_149	1_205
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					2HR7ATK059

INTERLEUKIN-4 RECEPTOR SUBUNIT ALPHA

TARGET->LIGAND

Amount:

Related Record Type Details


					B343W7ZE23

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	E	Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL