Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C20H19Cl2N3O3 |
| Molecular Weight | 420.289 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=CC=C(OC[C@H]2CO[C@@](CN3C=CN=C3)(O2)C4=C(Cl)C=C(Cl)C=C4)C=C1
InChI
InChIKey=JJAHMLRQDQLJJE-PXNSSMCTSA-N
InChI=1S/C20H19Cl2N3O3/c21-14-1-6-18(19(22)9-14)20(12-25-8-7-24-13-25)27-11-17(28-20)10-26-16-4-2-15(23)3-5-16/h1-9,13,17H,10-12,23H2/t17-,20-/m0/s1
| Molecular Formula | C20H19Cl2N3O3 |
| Molecular Weight | 420.289 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 13:48:31 GMT 2023
by
admin
on
Sat Dec 16 13:48:31 GMT 2023
|
| Record UNII |
B2LSF85ZYF
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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13019744
Created by
admin on Sat Dec 16 13:48:31 GMT 2023 , Edited by admin on Sat Dec 16 13:48:31 GMT 2023
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PRIMARY | |||
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B2LSF85ZYF
Created by
admin on Sat Dec 16 13:48:31 GMT 2023 , Edited by admin on Sat Dec 16 13:48:31 GMT 2023
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PRIMARY | |||
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67914-45-8
Created by
admin on Sat Dec 16 13:48:31 GMT 2023 , Edited by admin on Sat Dec 16 13:48:31 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> METABOLITE INACTIVE |
Evidence that CYP3A4 plays a significant role in metabolism of ketoconazole is that co-administration of CYP3A4 inducers, such as phenytoin, carbamazepine, and rifampin, can cause as much as a 50% reduction in levels of ketoconazole.
MAY BE CLINICALLY SIGNIFICANT
|
