Duvakitug

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 13:39:27 GMT 2023` Edited by `admin` on `Sat Dec 16 13:39:27 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	B2I7YTE4ZA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Duvakitug

Official Name

English

gamma1 heavy chain Homo sapiens (1-448) [VH (Homo sapiens IGHV1-8*01 (92.9%) -(IGHD) -IGHJ4*01 (92.9%),CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119)-Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12,L14 (CH1 K120 (216) (120-217), hinge 1-15 (218-

Common Name

English

duvakitug [INN]

Common Name

English

Immunoglobulin G1 [de-449-lysine], anti-(human tumor necrosis factor superfamily protein TNFSF15) (human monoclonal TEV-48574 γ1-chain), disulfide with human monoclonal TEV-48574 λ-chain, dimer

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C199032

Created by admin on Sat Dec 16 13:39:27 GMT 2023 , Edited by admin on Sat Dec 16 13:39:27 GMT 2023

PRIMARY

CAS

2750005-84-4

Created by admin on Sat Dec 16 13:39:27 GMT 2023 , Edited by admin on Sat Dec 16 13:39:27 GMT 2023

PRIMARY

FDA UNII

B2I7YTE4ZA

Created by admin on Sat Dec 16 13:39:27 GMT 2023 , Edited by admin on Sat Dec 16 13:39:27 GMT 2023

PRIMARY

INN

12561

Created by admin on Sat Dec 16 13:39:27 GMT 2023 , Edited by admin on Sat Dec 16 13:39:27 GMT 2023

PRIMARY

From	To
1_22	1_96
1_146	1_202
1_222	3_215
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427
2_22	2_96
2_146	2_202
2_222	4_215
2_263	2_323
2_369	2_427
3_22	3_90
3_138	3_197
4_138	4_197
4_22	4_90

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					NO7Z247RXI

TL1A

TARGET -> INHIBITOR

Comments:

neutralizing antibody that blocks the binding of TL1A to its cognate signaling receptor, death receptor 3 (DR3)

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL