DIMEDONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H12O2
Molecular Weight	140.1797
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)CC(=O)CC(=O)C1

InChI

InChIKey=BADXJIPKFRBFOT-UHFFFAOYSA-N

InChI=1S/C8H12O2/c1-8(2)4-6(9)3-7(10)5-8/h3-5H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C8H12O2
Molecular Weight	140.1797
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Reactivity of functionalized N,S-ketene acetal: regioselective construction of tetrahydrobenzo[b]pyran and chromeno[2,3-b]quinoline derivatives.	2010-12-17	21087000
Methaneseleninic acid is a substrate for truncated mammalian thioredoxin reductase: implications for the catalytic mechanism and redox signaling.	2010-12-07	21038895
Sulfamic acid catalyzed solvent-free synthesis of 10-aryl-7,7-dimethyl-6,7,8,10-tetrahydro-9H-[1,3]-dioxolo [4,5- b]xanthen-9-ones and 12-aryl-9,9-dimethyl-8,9,10,12-tetrahydro-11H-benzo[a]xanthen-11-ones.	2010-11	19789988
Synthesis of new nonclassical acridines, quinolines, and quinazolines derived from dimedone for biological evaluation.	2010-09	20814944
Synthesis of quinolone substituted pyrazoles, isoxazoles and pyridines as a potential blue luminophors.	2010-09	20354785
Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel.	2010-07-19	20557086
Formation of cysteine sulfenic acid by oxygen atom transfer from nitrite.	2010-07-14	20565124
Possibilities and pitfalls in quantifying the extent of cysteine sulfenic acid modification of specific proteins within complex biofluids.	2010-07-01	20594348
Effects of dietary sodium on performance, flight and compensation strategies in the cotton bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae).	2010-04-13	20385025
Ultrasound-assisted three-component synthesis of 3-(5-amino-1H-pyrazol-4-yl)-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)indolin-2-ones in water.	2010-03	20022284
Ionic liquid-promoted multi-component reaction: novel and efficient preparation of pyrazolo[3,4-b]pyridinone, pyrazolo[3,4-b]-quinolinone and their hybrids with pyrimidine nucleoside.	2010-02	19521790
Formation and reactions of sulfenic acid in human serum albumin.	2010	20513474
Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins.	2010	20513473
Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins.	2010	20513472
9,9-Dimethyl-12-(4-nitro-phen-yl)-9,10-dihydro-12H-benzo[a]xanthen-11(8H)-one.	2009-11-21	21578862
Simple and convenient approach to the Kreohnke pyridine type synthesis of functionalized indol-3-yl pyridine derivatives using 3-cyanoacetyl indole.	2009-11-13	19905001
Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases.	2009-11-13	19755417
9,9-Dimethyl-12-phenyl-8,9-dihydro-12H-benzo[a]xanthen-11(10H)-one.	2009-11-07	21578757
"Danger" conditions increase sulfamethoxazole-protein adduct formation in human antigen-presenting cells.	2009-11	19666748
Syntheses of quaternary carbon-containing oxazatricycle and spiropyran libraries via multicomponent reactions and their molecular switching properties.	2009-10-29	19860449
Hemoglobin glutathionylation can occur through cysteine sulfenic acid intermediate: electrospray ionization LTQ-Orbitrap hybrid mass spectrometry studies.	2009-10-15	19493711
Ethyl 4-(3-hydroxy-phen-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxyl-ate.	2009-10-07	21578275
Diastereoselective synthesis of trans-2,3-dihydrofurans with pyridinium ylide assisted tandem reaction.	2009-10-02	19739607
7-Bromo-4-(7-bromo-3,3-dimethyl-1-oxo-2,3,4,9-tetra-hydro-1H-xanthen-9-yl)-3,3-dimethyl-2,3-dihydroxanthen-1(4H)-one ethanol solvate.	2009-09-12	21577903
Synthesis of new acridines and hydrazones derived from cyclic beta-diketone for cytotoxic and antiviral evaluation.	2009-09	19423201
9,9-Dimethyl-12-(3-nitro-phen-yl)-7,8,9,10,11,12-hexa-hydro-benz[a]acridin-11-one.	2009-08-29	21577677
Synthesis of symmetrical and non-symmetrical diimines from dimedone.	2009-06-24	19553899
Selective formation of spiro dihydrofurans and cyclopropanes through unexpected reaction of aldehydes with 1,3-dicarbonyl compounds.	2009-06-04	19388701
An efficient one-pot three-component synthesis of fused 1,4-dihydropyridines using HY-zeolite.	2009-04-08	19384278
Potential role of formaldehyde in the mechanism of action of ascorbigens on the basis of BioArena studies.	2009-04	19039806
Microwave-induced synthesis and anti-microbial activities of 7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives.	2009-03	18718695
Chemical dissection of an essential redox switch in yeast.	2009-02-27	19230722
Efficient synthesis of spiro[chromeno[2,3-d]pyrimidine-5,3'-indoline]-tetraones by a one-pot and three-component reaction.	2009-02-26	19239200
Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel.	2009-02	19170597
Measurement of protein sulfenic acid content.	2008-11	20963754
Toward a prostate specific antigen-based prostate cancer diagnostic assay: preparation of keyhole limpet hemocyanin-conjugated normal and transformed prostate specific antigen fragments.	2008-10-15	18798614
A Clean synthesis of spiro[indoline-3,9'-xanthene]trione derivatives.	2008-09	18758112
One-pot synthesis and antibacterial activities of novel 1H-pyridazino[1,2-a]indazole-1,6,9(2H,11H)-triones.	2008-09	18758103
9-(4-Fluoro-phen-yl)-3,3,6,6-tetra-methyl-10-p-tolyl-1,2,3,4,5,6,7,8,9,10-deca-hydroacridine-1,8-dione.	2008-08-30	21201815
10-(4-Chloro-phen-yl)-9-(4-fluoro-phen-yl)-3,3,6,6-tetra-methyl-3,4,6,7,9,10-hexa-hydro-acridine-1,8(2H,5H)-dione.	2008-08-16	21201754
3,3-Dimethyl-9-phenyl-3,4-dihydro-acridin-1(2H)-one.	2008-07-19	21203257
3,3-Dimethyl-1,2,3,4,6,11-hexa-hydro-benzo[d]naphtho[2,3-b]furan-1,6,11-trione.	2008-07-19	21203239
A three component one-pot procedure for the synthesis of [1,2,4]triazolo/benzimidazolo-quinazolinone derivatives in the presence of H6P2W18O(62).18H2O as a green and reusable catalyst.	2008-06-05	18780153
Important bioactive molecules of erythrocytes in colorectal cancer patients after colectomy.	2008-02-27	19662138
8,8-Dimethyl-5-(4-methyl-phen-yl)-8,9-dihydro-pyrimido[4,5-b]quinoline-2,4,6(1H,3H,7H)-trione N,N-dimethyl-formamide solvate.	2008-02-20	21201942
9-(2,3-Dichloro-phen-yl)-4a-hydr-oxy-3,3,6,6-tetra-methyl-4,4a,5,6,9,9a-hexa-hydro-3H-xanthene-1,8(2H,7H)-dione.	2008-01-25	21201538
Chronic experimental diabetes accelerates urinary elimination of deprenyl and its metabolites.	2008-01-10	19662137
2-Anilino-3-benzoyl-4-(2,5-dichloro-phen-yl)-7,7-dimethyl-5-oxo-5,6,7,8-tetra-hydro-4H-benzo[b]pyran.	2008-01-09	21201435
Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase.	2008	19157014
Fluorimetric flow injection analysis of trace amount of formaldehyde in environmental atmosphere with 5,5-dimethylcyclohexane-1,3-dione.	2002-12-06	18968865

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:59:06 GMT 2025` Edited by `admin` on `Mon Mar 31 19:59:06 GMT 2025`
Record UNII	B2B5DSX2FC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

5,5-DIMETHYL-1,3-CYCLOHEXANEDIONE

Preferred Name

English

DIMEDONE

Common Name

English

DIMETHYLDIHYDRORESORCINOL

Systematic Name

English

1,1-DIMETHYL-3,5-CYCLOHEXANEDIONE

Systematic Name

English

METHONE

Common Name

English

5,5-DIMETHYL-1,3-CYCLOHEXANEDIONE [MI]

Common Name

English

NSC-14984

Code

English

1,1-DIMETHYL-3,5-DIKETOCYCLOHEXANE

Systematic Name

English

Code System Code Type Description

EVMPD

SUB194232