FONAZINE MESYLATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25N3O2S2.CH4O3S
Molecular Weight	487.656
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(O)(=O)=O.CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)S(=O)(=O)N(C)C)N(C)C

InChI

InChIKey=JGKVKXPDDVRUKC-UHFFFAOYSA-N

InChI=1S/C19H25N3O2S2.CH4O3S/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5;1-5(2,3)4/h6-12,14H,13H2,1-5H3;1H3,(H,2,3,4)

HIDE SMILES / InChI

Molecular Formula	C19H25N3O2S2
Molecular Weight	391.551
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	CH4O3S
Molecular Weight	96.106
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.mufel.net/plm05/6816.htm
Curator's Comment: description was created based on several sources, including, https://www.jstage.jst.go.jp/article/gnam1977/3/2/3_113/_pdf, http://www.ncbi.nlm.nih.gov/pubmed/8564192

Fonzine (also known as dimetotiazine) is an analgesics and anti-inflammatory agent marketed in Japan and Europe under the name Migristene and indicated for the treatment of migraine and headaches secondary to other disease. Fonzine exerts its activity by inhibiting serotonin and histamine H1 receptors.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin (5-HT) receptor 34 Target ID: CHEMBL2096904 Sources: https://www.jstage.jst.go.jp/article/gnam1977/3/2/3_113/_pdf	Antagonist 2778
Histamine H1 receptor 315 Target ID: P35367 Gene ID: 3269.0 Gene Symbol: HRH1 Target Organism: Homo sapiens (Human) Sources: http://www.ncbi.nlm.nih.gov/pubmed/8564192	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Migraine 103 Sources: http://www.mufel.net/plm05/6816.htm	Primary		Approved 8429	MIGRISTENE Approved Use Prophylactic and curative treatment of migraine and headaches secondary other diseases.
Secondary headache 3 Sources: http://www.mufel.net/plm05/6816.htm	Primary		Approved 8429	MIGRISTENE Approved Use Prophylactic and curative treatment of migraine and headaches secondary other diseases.

PubMed

Title	Date	PubMed
[Clinical use of dimetotiazine (8599RP)].	1967 Dec 10	5593375
[Resorption, excretion and biotransformation of 3-dimethylsulfamido-10-(2-dimethylaminopropyl)-phenothiazine (Dimetotiazine) in the rabbit and dog].	1967 Sep-Oct	5583624
Determination of isothipendyl or dimethothiazine with their sulphoxides using third- and fourth-derivatives spectroscopy on a diode-array spectrophotometer.	1990 Jul-Aug	2290121

Patents

Sample Use Guides

In Vivo Use Guide

Take 20-80 mg during the first day (2-4 tablets) and then - 40 mg/day (2 tablets) up to 3 months.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:19:12 UTC 2023` Edited by `admin` on `Fri Dec 15 17:19:12 UTC 2023`
Record UNII	B28V86NGNK
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FONAZINE MESYLATE

Official Name

English

FONAZINE MESILATE

Common Name

English

10H-PHENOTHIAZINE-2-SULFONAMIDE, 10-(2-(DIMETHYLAMINO)PROPYL)-N,N-DIMETHYL-, MONOMETHANESULFONATE

Systematic Name

English

10H-PHENOTHIAZINE-2-SULPHONAMIDE, 10-(2-(DIMETHYLAMINO)PROPYL)-N,N-DIMETHYL-, MONOMETHANESULPHONATE

Systematic Name

English

DIMETOTIAZINE MESILATE [MART.]

Common Name

English

DIMETHOTHIAZINE MESYLATE

Common Name

English

PROMAQUID

Brand Name

English

NEOMESTINE

Brand Name

English

10-[2-(Dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide monomethanesulfonate

Systematic Name

English

FONAZINE MESYLATE [USAN]

Common Name

English

IL-6302 MESYLATE

Code

English

CALSEKIN

Brand Name

English

8599 R.P. MESILATE

Common Name

English

IL-6302 MESILATE

Common Name

English

Dimetotiazine mesilate [WHO-DD]

Common Name

English

FONAZINE METHANESULFONATE [MI]

Common Name

English

FONAZINE METHANESULFONATE

Common Name

English

BONPAC

Brand Name

English

BANISTYL

Brand Name

English

YORISTEN

Brand Name

English

MIGRISTNE

Brand Name

English

DIMETOTIAZINE MESILATE

Common Name

English

DIMETOTIAZINE MESILATE [JAN]

Common Name

English

10-(2-(DIMETHYLAMINO)PROPYL)-N,N-DIMETHYLPHENOTHIAZINE-2-SULPHONAMIDE MONOMETHANESULPHONATE

Systematic Name

English

DIMETHOTHIAZINE MESILATE

Common Name

English

8599 R.P. MESYLATE

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C66885