Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C10H13N5O5S |
| Molecular Weight | 315.306 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC2=C(NC(=S)N2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
InChI
InChIKey=KZELNMSPWPFAEB-UMMCILCDSA-N
InChI=1S/C10H13N5O5S/c11-9-13-6-3(7(19)14-9)12-10(21)15(6)8-5(18)4(17)2(1-16)20-8/h2,4-5,8,16-18H,1H2,(H,12,21)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s1
| Molecular Formula | C10H13N5O5S |
| Molecular Weight | 315.306 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Activation of lymphocytes by a thiol-derivatized nucleoside: characterization of cellular parameters and responsive subpopulations. | 1983 Feb |
|
| Derivatized guanine nucleosides: a new class of adjuvant for in vitro antibody responses. | 1983 Jun |
|
| Mechanism of 8-mercaptoguanosine-mediated adjuvanticity: roles of clonal expansion and cellular recruitment. | 1984 Dec |
|
| Regulation of B-lymphocyte proliferative responses by arachidonate metabolites: effects on membrane-directed versus intracellular activators. | 1984 Sep |
|
| Restoration of humoral immunity in vitro in immunodeficient aging mice by C8-derivatized guanine ribonucleosides. | 1985 Jun |
|
| Control of B cell proliferation: inhibition of responses to B cell mitogens induced by plasma cell tumors. | 1985 May |
|
| Queuosine metabolism: possible relation to B-cell activation by C8 derivatives of guanosine. | 1985 Sep |
|
| Distinct effects of dual substitution on inductive and differentiative activities of C8-substituted guanine ribonucleosides. | 1986 Oct 15 |
|
| "Numatrin," a nuclear matrix protein associated with induction of proliferation in B lymphocytes. | 1987 Aug 15 |
|
| Large, activated B cells are the primary B-cell target of 8-bromoguanosine and 8-mercaptoguanosine. | 1987 May |
|
| Inducible Ig heavy chain switching in an IgM+ Ly-1 B cell line. Evidence for a state of switch commitment. | 1988 |
|
| 5-Halo-6-phenyl pyrimidinones and 8-substituted guanosines: biological response modifiers with similar effects on B cells. | 1988 Mar |
|
| 8-Mercaptoguanosine overcomes unresponsiveness of human neonatal B cells to polysaccharide antigens. | 1988 Oct 1 |
|
| Role of salvage and phosphorylation in the immunostimulatory activity of C8-substituted guanine ribonucleosides. | 1988 Oct 1 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:14:39 GMT 2023
by
admin
on
Fri Dec 15 18:14:39 GMT 2023
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| Record UNII |
B0T9FOW56N
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID30948906
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686300-03-8
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NON-SPECIFIC STEREOCHEMISTRY | |||
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26001-38-7
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135457302
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247-402-4
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79216
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B0T9FOW56N
Created by
admin on Fri Dec 15 18:14:39 GMT 2023 , Edited by admin on Fri Dec 15 18:14:39 GMT 2023
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PRIMARY |