EVONCABTAGENE PAZURGEDLEUCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 18:55:55 UTC 2023` Edited by `admin` on `Sat Dec 16 18:55:55 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BLOOD
Fraction Name	Peripheral blood
Record UNII	AZS2UCV4V3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EVONCABTAGENE PAZURGEDLEUCEL

Official Name

English

evoncabtagene pazurgedleucel [INN]

Common Name

English

ALLOGENEIC T CELLS OBTAINED FROM PERIPHERAL BLOOD BY LEUKAPHERESIS, GENETICALLY MODIFIED BY RISPR/CAS9 (CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS/CRISPR-ASSOCIATED PROTEIN 9) MEDIATED GENE EDITING CONSISTING OF TWO GUIDE RNAS (GRNAS) INTR

Common Name

English

Code System Code Type Description

FDA UNII

AZS2UCV4V3

Created by admin on Sat Dec 16 18:55:55 UTC 2023 , Edited by admin on Sat Dec 16 18:55:55 UTC 2023

PRIMARY

INN

11599

Created by admin on Sat Dec 16 18:55:55 UTC 2023 , Edited by admin on Sat Dec 16 18:55:55 UTC 2023

PRIMARY

Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					AZS2UCV4V3

EVONCABTAGENE PAZURGEDLEUCEL

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
	TRANSFECTION		EVONCABTAGENE PAZURGEDLEUCEL VECTOR	U4M42FA22J
CULTURE	EXPANSION		HUMAN INTERLEUKIN-2	FNO32LO217
CULTURE	EXPANSION		INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71
ELECTROPORATION	GENE TRUNCATION	GENE MODIFICATION	EVONCABTAGENE PAZURGEDLEUCEL SINGLE GUIDE RNA (SGRNA) TARGETING THE TRAC LOCUS	FKP72X9XKK
ELECTROPORATION	GENE TRUNCATION	GENE MODIFICATION	EVONCABTAGENE PAZURGEDLEUCEL SINGLE GUIDE RNA (SGRNA) TARGETING THE .BETA.2M LOCUS	EQW8RVL4CV

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					EVONCABTAGENE PAZURGEDLEUCEL EXPRESSED ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR	99C5N75ES4
INSERTED GENE EXPRESSION VECTOR					EVONCABTAGENE PAZURGEDLEUCEL TRANSGENE INSERT	CU6ER36WJ5