ZAGOTENEMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:34:08 GMT 2023` Edited by `admin` on `Sat Dec 16 14:34:08 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	AY6V5E2GNX
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ZAGOTENEMAB

Official Name

English

LY-3303560

Code

English

zagotenemab [INN]

Common Name

English

LY3303560

Code

English

IMMUNOGLOBULIN G4, ANTI-(TAU PROTEIN) (HUMAN MONOCLONAL LY3303560 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL LY3303560 LIGHT CHAIN, DIMER

Common Name

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS MICROTUBULE-ASSOCIATED PROTEIN TAU (NEUROFIBRILLARY TANGLE PROTEIN, PHF-TAU)) HUMANIZED MONOCLONAL ANTIBODY .GAMMA.4 HEAVY CHAIN (1-442) (HUMANIZED VH (HOMO SAPIENS IGHV5-51*01 (85%) (IGHD)-IGHJ4*01 (87%)) (8.8

Common Name

English

ZAGOTENEMAB [USAN]

Common Name

English

Code System Code Type Description

CAS

2019133-28-7

Created by admin on Sat Dec 16 14:34:08 GMT 2023 , Edited by admin on Sat Dec 16 14:34:08 GMT 2023

PRIMARY

FDA UNII

AY6V5E2GNX

Created by admin on Sat Dec 16 14:34:08 GMT 2023 , Edited by admin on Sat Dec 16 14:34:08 GMT 2023

PRIMARY

USAN

FG-107

Created by admin on Sat Dec 16 14:34:08 GMT 2023 , Edited by admin on Sat Dec 16 14:34:08 GMT 2023

PRIMARY

INN

11050

Created by admin on Sat Dec 16 14:34:08 GMT 2023 , Edited by admin on Sat Dec 16 14:34:08 GMT 2023

PRIMARY

NCI_THESAURUS

C171842

Created by admin on Sat Dec 16 14:34:08 GMT 2023 , Edited by admin on Sat Dec 16 14:34:08 GMT 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_130	4_219
2_143	2_199
2_257	2_317
1_130	3_219
2_363	2_421
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_143	1_199
1_222	2_222
1_225	2_225
1_257	1_317
1_363	1_421

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_293
N	2_293

Related Record Type Details


					QR9EFE0TG6

MICROTUBULE-ASSOCIATED PROTEIN TAU (PAIRED HELICAL FILAMENTS (PHF))

TARGET->LIGAND

Comments:

Designed to bind to and neutralize tau clumps, slowing or stopping the worsening of Alzheimer’s.

Amount:

Related Record Type Details


					AY6V5E2GNX

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL