Trovostobart

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 15:32:02 GMT 2025` Edited by `admin` on `Wed Apr 02 15:32:02 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	ATY7DC4MSF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Trovostobart

Official Name

English

KVA-12123

Preferred Name

English

H-gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV4-59*01 (99.0%) -(IGHD) -IGHJ3*02 (93.3%) T125>I (114), CDR-IMGT [8.7.11] (26-33.51-57.96-106)) (1-117) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, 9-G1v21 CH2 Y15.1, T16, E18 (C

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens VSIR (V-set immunoregulatory receptor, B7H5, B7-H5, PDCD1 homolog, PD-1H, stress induced secreted protein 1, SISP1, V-domain Ig suppressor of T cell activation, VISTA)], Homo sapiens monoclonal antibody (trovos

Common Name

English

trovostobart [INN]

Common Name

English

KVA12123

Code

English

Immunoglobulin G1 [252-tyrosine,254-threonine,256-glutamic acid], anti-(human v-domain immunoglobulin suppressor of T-cell activation) (human monoclonal KVA12123 ?1-chain), disulfide with human monoclonal KVA12123 ?-chain, dimer

Common Name

English

Code System Code Type Description

INN

13453

Created by admin on Wed Apr 02 15:32:02 GMT 2025 , Edited by admin on Wed Apr 02 15:32:02 GMT 2025

PRIMARY

FDA UNII

ATY7DC4MSF

Created by admin on Wed Apr 02 15:32:02 GMT 2025 , Edited by admin on Wed Apr 02 15:32:02 GMT 2025

PRIMARY

CAS

3006784-09-1

Created by admin on Wed Apr 02 15:32:02 GMT 2025 , Edited by admin on Wed Apr 02 15:32:02 GMT 2025

PRIMARY

From	To
1_22	1_95
2_22	2_95
2_144	2_200
2_220	4_214
2_261	2_321
1_144	1_200
2_367	2_425
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_220	3_214
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					ATY7DC4MSF

Trovostobart

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_447] [2_447]	C-TERMINUS	K		LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL