Ufrenmeran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 19:22:23 UTC 2023` Edited by `admin` on `Sat Dec 16 19:22:23 UTC 2023`
Nucleic Acid Type	MRNA
Nucleic Acid Subtype	TRANSGENE
Sequence Type	COMPLETE
Record UNII	AP7FFK83RM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ufrenmeran

Official Name

English

messenger RNA (mRNA), 5'-capped, encoding the codon-optimized receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, Wuhan-Hu-1 isolate, GenBank: MN908947.3) spike (S) glycoprotein, expressed as a fusion protein

Common Name

English

ufrenmeran [INN]

Common Name

English

RNA (recombinant 5′-(m7G-(5′→5′)-ppp-Am)-capped all cytidine→5-methylcytidine, all uridine→5-methyluridine human β-globin 5′-untranslated region plus severe acute respiratory syndrome coronavirus 2 strain Wuhan-Hu-1 (1-13)-(319-541)-spike

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C190418

Created by admin on Sat Dec 16 19:22:24 UTC 2023 , Edited by admin on Sat Dec 16 19:22:24 UTC 2023

PRIMARY

CAS

2749556-96-3

Created by admin on Sat Dec 16 19:22:24 UTC 2023 , Edited by admin on Sat Dec 16 19:22:24 UTC 2023

PRIMARY

FDA UNII

AP7FFK83RM

Created by admin on Sat Dec 16 19:22:24 UTC 2023 , Edited by admin on Sat Dec 16 19:22:24 UTC 2023

PRIMARY

INN

12540

Created by admin on Sat Dec 16 19:22:24 UTC 2023 , Edited by admin on Sat Dec 16 19:22:24 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_1022	1022 / 1022

Linkage	Site Range	Site Count
Phosphate	1_2-1_1022	1021 / 1021

Related Record Type Details


					YT6ZGY2CE2

SARS COV-2 RECEPTOR BINDING DOMAIN

EXPRESSED PROTEIN->VECTOR

Amount:


					B6L4N5Z4GH

SARS-COV2

TARGET->VACCINE ANTIGEN

Amount:

Related Record Type Details


					AP7FFK83RM

Ufrenmeran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Fragment Name	Fragment Approval
NUCLEOTIDE INSERTIONS	[1_1]	5'-TERMINUS		m2-7,3’-OGppp(m1-2’-O)Ap mRNA CAP	VNP8CZY34V
NUCLEOSIDE BASE SUBSTITUTION		RESIDUE_SPECIFIC	C	5-METHYLCYTOSINE	6R795CQT4H
NUCLEOSIDE BASE SUBSTITUTION		RESIDUE_SPECIFIC	U	THYMINE	QR26YLT7LT