.BETA.-AMYRIN ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C32H52O2
Molecular Weight	468.7541
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC(C)(C)CC[C@]1(C)CC[C@]3(C)C2=CC[C@]4([H])[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@]5([H])CC[C@@]34C

InChI

InChIKey=UMRPOGLIBDXFNK-ZYGITSNFSA-N

InChI=1S/C32H52O2/c1-21(33)34-26-13-14-30(7)24(28(26,4)5)12-15-32(9)25(30)11-10-22-23-20-27(2,3)16-17-29(23,6)18-19-31(22,32)8/h10,23-26H,11-20H2,1-9H3/t23-,24-,25+,26-,29+,30-,31+,32+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C32H52O2
Molecular Weight	468.7541
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20484832
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18926710 | https://www.ncbi.nlm.nih.gov/pubmed/19831026

Beta-Amyrin Acetate is β-Amyrin derivative with potent anti-inflammatory, anti-diabetic, anti-hyperlipidemic activities.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Diabetic retinopathy 17 Sources: http://www.google.com/patents/CN106692422A	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Biotransformation of beta-amyrin acetate by Rhodobacter sphaeroides.	2008 May	18558349

Patents

Sample Use Guides

In Vivo Use Guide

In 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation mouse model Beta-Amyrin Acetate shows potent anti-inflammatory activity with ID50=0.75mkM/ear

Route of Administration: Topical

In Vitro Use Guide

The murine microglia cell line, BV2, was used for activity evaluation. BV2 cells were cultured in Dulbecco’s modified Eagle medium (Gibco, USA) supplemented with 5% fetal bovine serum (Hyclone). Cells were treated with Beta-Amyrin Acetate (up to 50 mkM). Production of NO was measured by the accumulation of nitrite in the culture medium 24 h after stimulation with LPS (0.5 mkg/ml) or IFN (20 ng/ml) by the Griess reagent.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:50:46 GMT 2023` Edited by `admin` on `Fri Dec 15 18:50:46 GMT 2023`
Record UNII	AM1H7102OC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

.BETA.-AMYRIN ACETATE

Common Name

English

OLEAN-12-EN-3-OL, 3-ACETATE, (3.BETA.)-

Systematic Name

English

NSC-403166

Code

English

Code System Code Type Description

FDA UNII

AM1H7102OC