Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C32H52O2 |
| Molecular Weight | 468.7541 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC(C)(C)CC[C@]1(C)CC[C@]3(C)C2=CC[C@]4([H])[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@]5([H])CC[C@@]34C
InChI
InChIKey=UMRPOGLIBDXFNK-ZYGITSNFSA-N
InChI=1S/C32H52O2/c1-21(33)34-26-13-14-30(7)24(28(26,4)5)12-15-32(9)25(30)11-10-22-23-20-27(2,3)16-17-29(23,6)18-19-31(22,32)8/h10,23-26H,11-20H2,1-9H3/t23-,24-,25+,26-,29+,30-,31+,32+/m0/s1
| Molecular Formula | C32H52O2 |
| Molecular Weight | 468.7541 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18926710 | https://www.ncbi.nlm.nih.gov/pubmed/19831026
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/18926710 | https://www.ncbi.nlm.nih.gov/pubmed/19831026
Beta-Amyrin Acetate is β-Amyrin derivative with potent anti-inflammatory, anti-diabetic, anti-hyperlipidemic activities.
Originator
Approval Year
Sample Use Guides
In 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation mouse model Beta-Amyrin Acetate shows potent anti-inflammatory activity with ID50=0.75mkM/ear
Route of Administration:
Topical
The murine microglia cell line, BV2, was used for activity evaluation. BV2 cells were cultured in Dulbecco’s modified Eagle medium (Gibco, USA) supplemented with 5% fetal bovine serum (Hyclone). Cells were treated with Beta-Amyrin Acetate (up to 50 mkM). Production of NO was measured by the accumulation of nitrite in the culture medium 24 h after stimulation with LPS (0.5 mkg/ml) or IFN (20 ng/ml) by the Griess reagent.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:50:46 GMT 2023
by
admin
on
Fri Dec 15 18:50:46 GMT 2023
|
| Record UNII |
AM1H7102OC
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
AM1H7102OC
Created by
admin on Fri Dec 15 18:50:46 GMT 2023 , Edited by admin on Fri Dec 15 18:50:46 GMT 2023
|
PRIMARY | |||
|
403166
Created by
admin on Fri Dec 15 18:50:46 GMT 2023 , Edited by admin on Fri Dec 15 18:50:46 GMT 2023
|
PRIMARY | |||
|
1616-93-9
Created by
admin on Fri Dec 15 18:50:46 GMT 2023 , Edited by admin on Fri Dec 15 18:50:46 GMT 2023
|
PRIMARY | |||
|
DTXSID50936562
Created by
admin on Fri Dec 15 18:50:46 GMT 2023 , Edited by admin on Fri Dec 15 18:50:46 GMT 2023
|
PRIMARY | |||
|
92156
Created by
admin on Fri Dec 15 18:50:46 GMT 2023 , Edited by admin on Fri Dec 15 18:50:46 GMT 2023
|
PRIMARY |