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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 11:53:34 GMT 2025
Edited
by admin
on Wed Apr 02 11:53:34 GMT 2025
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1|KAPPA
Sequence Type COMPLETE
Record UNII
AJN3EUF4Z9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Olintatug Tesirine
INN  
Official Name English
H-gamma1 heavy chain humanized (1-445) [VH (Homo sapiens IGHV1-46*01 (80.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.9] (26-33.51-58.97-105)) (1-116) -Homo sapiens IGHG1*01 (100%), G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (213) (117-214), hinge 1-15 (215
Preferred Name English
olintatug tesirine [INN]
Common Name English
Immunoglobulin G1 [de-C-terminal-lysine], anti-(human kidney-associated antigen 1) (human-Mus musculus monoclonal 3A4 ?1-chain), disulfide with human-Mus musculus monoclonal 3A4 ?-chain, dimer, reduced, thioether with N-[31-(3-mercapto-2,5-dioxo-1-pyrrol
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiens KAAG1 (kidney associated DCDC2 antisense RNA 1, kidney associated antigen 1, RU2AS, RU2 antisense gene protein)], humanized and chimeric monoclonal antibody, conjugated on an average of 2-3 cysteinyl residues t
Common Name English
Code System Code Type Description
SMS_ID
300000040792
Created by admin on Wed Apr 02 11:53:34 GMT 2025 , Edited by admin on Wed Apr 02 11:53:34 GMT 2025
PRIMARY
INN
13015
Created by admin on Wed Apr 02 11:53:34 GMT 2025 , Edited by admin on Wed Apr 02 11:53:34 GMT 2025
PRIMARY
CAS
2851870-30-7
Created by admin on Wed Apr 02 11:53:34 GMT 2025 , Edited by admin on Wed Apr 02 11:53:34 GMT 2025
PRIMARY
NCI_THESAURUS
C181996
Created by admin on Wed Apr 02 11:53:34 GMT 2025 , Edited by admin on Wed Apr 02 11:53:34 GMT 2025
PRIMARY
FDA UNII
AJN3EUF4Z9
Created by admin on Wed Apr 02 11:53:34 GMT 2025 , Edited by admin on Wed Apr 02 11:53:34 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_143 2_199
2_219 4_219
2_260 2_320
1_143 1_199
2_366 2_424
3_23 3_93
3_139 3_199
4_23 4_93
4_139 4_199
1_219 3_219
1_225 2_225
1_228 2_228
1_260 1_320
1_366 1_424
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details
Olintatug Tesirine
ACTIVE MOIETY
ADCT-901 bound to and selectively inhibited the growth of a panel of KAAG1-positive human cancer cell lines including SK-OV-3, MDA-MB-231, SN12C, PC3, and IGROV-1, while its activity was strongly reduced in the KAAG1-negative cell lines SW620 and K562
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE CHEMICAL
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
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