U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Tue Apr 01 21:26:42 GMT 2025
Edited
by admin
on Tue Apr 01 21:26:42 GMT 2025
Nucleic Acid Type OLIGONUCLEOTIDE
Sequence Type COMPLETE
Record UNII
AIW6036FAS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EXONDYS 51 COMPONENT ETEPLIRSEN
Preferred Name English
ETEPLIRSEN
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
Eteplirsen [WHO-DD]
Common Name English
ETEPLIRSEN [USAN]
Common Name English
ETEPLIRSEN [ORANGE BOOK]
Common Name English
AVI-4658
Code English
eteplirsen [INN]
Common Name English
ETEPLIRSEN [MI]
Common Name English
Classification Tree Code System Code
WHO-ATC M09AX06
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
NDF-RT N0000191626
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
FDA ORPHAN DRUG 248407
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
Code System Code Type Description
ChEMBL
CHEMBL2108278
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
EMA ASSESSMENT REPORTS
Exondys (Refused)
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
SMS_ID
100000155279
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
DRUG CENTRAL
5182
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
NCI_THESAURUS
C171739
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
DAILYMED
AIW6036FAS
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
EVMPD
SUB129287
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
INN
9339
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
RXCUI
1810569
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
NDF-RT
N0000011392
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY Oligonucleotides, Antisense [Chemical/Ingredient]
WIKIPEDIA
ETEPLIRSEN
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
USAN
XX-107
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
MERCK INDEX
m12193
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
DRUG BANK
DB06014
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
FDA UNII
AIW6036FAS
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
EPA CompTox
DTXSID701027882
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
CAS
1173755-55-9
Created by admin on Tue Apr 01 21:26:42 GMT 2025 , Edited by admin on Tue Apr 01 21:26:42 GMT 2025
PRIMARY
Sugar Site Range Site Count
morpholino 1_1-1_30 30 / 30
Linkage Site Range Site Count
Phosphoryldimethylamine 1_2-1_30 29 / 29
Related Record Type Details
BINDER->LIGAND
BINDING
TARGET -> INDUCER
Exon 51 skipping. Eteplirsen is a morpholino antisense oligomer which triggers excision of exon 51 during pre-mRNA splicing of the dystrophin RNA transcript.
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOTIDE SUBSTITUTION [1_1] SITE_SPECIFIC CASIMERSEN 5'-CYTOSINE MODIFICATION 8CQO07490I