CLOCINIZINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C26H27ClN2.2ClH
Molecular Weight	475.881
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.ClC1=CC=C(C=C1)C(N2CCN(C\C=C\C3=CC=CC=C3)CC2)C4=CC=CC=C4

InChI

InChIKey=YFQRGPYJACKPRU-WRQJSNHTSA-N

InChI=1S/C26H27ClN2.2ClH/c27-25-15-13-24(14-16-25)26(23-11-5-2-6-12-23)29-20-18-28(19-21-29)17-7-10-22-8-3-1-4-9-22;;/h1-16,26H,17-21H2;2*1H/b10-7+;;

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C26H27ClN2
Molecular Weight	402.959
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	1
Optical Activity	( + / - )

Description
Sources: https://www.vademecum.es/medicamento-senioral_ficha_3612

Clocinizine is an antihistamine derivative of diphenylmethylpiperazine. Clocinizine is a competitive and reversible H1 receptor antagonist. The drug is marketed in Spain under tradename Senioral in combination with phenylpropanolamine for temporary relief of nasal congestion in colds, rhinitis, and sinusitis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 315 Target ID: CHEMBL231 Sources: https://www.drugs.com/international/clocinizine.html \| http://www.hmdb.ca/metabolites/HMDB0240242	Antagonist 2778

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:16:24 UTC 2023` Edited by `admin` on `Fri Dec 15 17:16:24 UTC 2023`
Record UNII	AE8KM1QU3Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CLOCINIZINE HYDROCHLORIDE

Common Name

English

1-((4-CHLOROPHENYL)PHENYLMETHYL)-4-(3-PHENYL-2-PROPENYL)PIPERAZINE DIHYDROCHLORIDE

Systematic Name

English

CLOCINIZINE DIHYDROCHLORIDE

Common Name

English

Clocinizine hydrochloride [WHO-DD]

Common Name

English

PIPERAZINE, 1-((4-CHLOROPHENYL)PHENYLMETHYL)-4-(3-PHENYL-2-PROPEN-1-YL)-, HYDROCHLORIDE (1:2)

Systematic Name

English

CLOCINIZINE HYDROCHLORIDE [MART.]

Common Name

English

CLIOCINIZINE HYDROCHLORIDE

Common Name

English

1-CINNAMYL-4-(4-CHLOROBENZHYDRYL)PIPERAZINE DIHYDROCHLORIDE

Systematic Name

English

CLOCINIZINE HCL

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578