Approval Year
| Substance Class |
Structurally Diverse
Created
by
admin
on
Edited
Sat Dec 16 19:23:29 GMT 2023
by
admin
on
Sat Dec 16 19:23:29 GMT 2023
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| Source Materials Class | ORGANISM |
| Source Materials Type | BACTERIUM |
| Organism Family | Enterobacteriaceae |
| Organism Genus | Escherichia |
| Organism Species | Escherichia coli |
| Infraspecific Type | STRAIN:SUBSTRAIN |
| Infraspecific Name | SYNB1934 (E.coli/LAAD/PheP/mPAL/del dapA/Inactivation of the endogenous Nissle prophage) |
| Part | whole |
| Record UNII |
ABR4S53CKC
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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ABR4S53CKC
Created by
admin on Sat Dec 16 19:23:29 GMT 2023 , Edited by admin on Sat Dec 16 19:23:29 GMT 2023
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PRIMARY | |||
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12595
Created by
admin on Sat Dec 16 19:23:29 GMT 2023 , Edited by admin on Sat Dec 16 19:23:29 GMT 2023
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PRIMARY | |||
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C199064
Created by
admin on Sat Dec 16 19:23:29 GMT 2023 , Edited by admin on Sat Dec 16 19:23:29 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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EXPRESSED PROTEIN->VECTOR |
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PARENT ORGANISM -> INFRASPECIFIC |
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EXPRESSED PROTEIN->VECTOR |
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EXPRESSED PROTEIN->VECTOR |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
SYNB1934 is an engineered strain of Escherichia coli Nissle 1917 (EcN) that has been designed for the treatment of Phenylketonuria (PKU) through the conversion of phenylalanine to trans-cinnamic acid (TCA) and phenylpyruvate (PP), two nontoxic metabolites
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Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| INSERTED GENE EXPRESSION VECTOR | inserted downstream of the endogenous Nissle araC gene | Labafenogene marselecobac LacI-Ptac-mPAL insertion | BM7DPF4Z6U | |||
| INSERTED GENE EXPRESSION VECTOR | Labafenogene marselecobac PBAD-LAAD insertion | N29C69W7VN | ||||
| INSERTED GENE EXPRESSION VECTOR | Labafenogene marselecobac LacI-Ptac-pheP insertion | AXL2C5DY5R |