Apazunersen

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 06:38:49 GMT 2025` Edited by `admin` on `Wed Apr 02 06:38:49 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	ABG25J5B9G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CHIMERIC LOCKED NUCLEIC ACID AND RIBONUCLEIC-DEOXYRIBONUCLEIC ANTISENSE OLIGONUCLEOTIDE SPECIFIC FOR THE HUMAN UBE3A-ANTISENSE TRANSCRIPT

Preferred Name

English

Apazunersen

Official Name

English

apazunersen [INN]

Common Name

English

all-P-ambo-2'-O,4'-C-methylene-P-thioadenylyl-(3'?5')-2'-O,4'-C-methylene-P-thioguanylyl-(3'?5')-2'-O,4'-C-methylene-P-thioadenylyl-(3'?5')-2'-deoxy-P-thioadenylyl-(3'?5')-P-thiothymidylyl-(3'?5')-2'-deoxy-P-thioguanylyl-(3'?5')-2'-deoxy-P-thioguanylyl-(

Common Name

English

DNA, d(P-thio)((2?-O,4?-C-methylene)rA-(2?-O,4?-C-methylene)rG-(2?-O,4?-C-methylene)rA-A-T-G-G-C-A-C-A-T-C-T-(2?-O,4?-C-methylene)m5rC-(2?-O,4?-C-methylene)m5rU-(2?-O,4?-C-methylene)m5rU-(2?-O,4?-C-methylene)rG)

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

702619

Created by admin on Wed Apr 02 06:38:50 GMT 2025 , Edited by admin on Wed Apr 02 06:38:50 GMT 2025

Code System Code Type Description

INN

13469

Created by admin on Wed Apr 02 06:38:49 GMT 2025 , Edited by admin on Wed Apr 02 06:38:49 GMT 2025

PRIMARY

FDA UNII

ABG25J5B9G

Created by admin on Wed Apr 02 06:38:50 GMT 2025 , Edited by admin on Wed Apr 02 06:38:50 GMT 2025

PRIMARY

CAS

2919324-01-7

Created by admin on Wed Apr 02 06:38:50 GMT 2025 , Edited by admin on Wed Apr 02 06:38:50 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2,'4'-locked-Ribose (alpha-L-LNA)	1_1-1_3;1_15-1_18	7 / 18
Deoxyribose (DNA)	1_4-1_14	11 / 18

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_18	17 / 17

Related Record Type Details


					T8M879B42S

UBIQUITIN-PROTEIN LIGASE E3A

TARGET->INHIBITOR OF EXPRESSION

Amount:

Related Record Type Details


					ABG25J5B9G

Apazunersen

ACTIVE MOIETY

Amount: