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Details

Stereochemistry RACEMIC
Molecular Formula C3H8O2S
Molecular Weight 108.159
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MONOTHIOGLYCEROL

SMILES

OCC(O)CS

InChI

InChIKey=PJUIMOJAAPLTRJ-UHFFFAOYSA-N
InChI=1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2

HIDE SMILES / InChI
Molecular Formula C3H8O2S
Molecular Weight 108.159
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Monothioglycerol (3-Mercaptopropane-1,2-diol, thioglycerol), is a chemical compound and thiol that is used as a matrix in fast atom bombardment mass spectrometry and liquid secondary ion mass spectrometry.

Originator

Approval Year

1995
196
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
On the binding of complement to solid artificial surfaces in vitro.
2002 Feb
Structural and optical investigations of SiO2-CdS core-shell particles.
2004 Oct 1
Synthesis and optical properties of thiol-stabilized PbS nanocrystals.
2005 Feb 1
Thio arsenosugars in freshwater mussels from the Danube in Hungary.
2005 Jul
Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine.
2005 Nov
Effects of bismuth contamination on the growth and activity of soil microorganisms using thiols as model compounds.
2006
Emission properties of colloidal quantum dots on polyelectrolyte multilayers.
2006 Aug 28
Manipulation of aqueous growth of CdTe nanocrystals to fabricate colloidally stable one-dimensional nanostructures.
2006 Aug 9
Diastereoisomerism of thiol complexes of arsenic acids and pseudoasymmetry of arsenic: a 1H and 13C NMR study.
2006 Feb
The effect of surface attachment on ligand binding: studying the association of Mg2+, Ca2+ and Sr2+ by 1-thioglycerol and 1,4-dithiothreitol monolayers.
2006 Jan 7
Primordial germ cell specification from embryonic stem cells.
2008
Studies on optical absorption and photoluminescence of thioglycerol-stabilized CdS quantum dots.
2008 Dec 15
Thermochemical growth of Mn-doped CdS nanoparticles and study of luminescence evolution.
2008 Jun 4
Mechanism-based inactivation of coenzyme B12-dependent diol dehydratase by 3-unsaturated 1,2-diols and thioglycerol.
2008 Oct
Multipotent adult germ-line stem cells, like other pluripotent stem cells, can be killed by cytotoxic T lymphocytes despite low expression of major histocompatibility complex class I molecules.
2009 Aug 28
A comparative study of methylglyoxal metabolism in trypanosomatids.
2009 Jan
3-Fluoro-salicylaldoxime at 6.5 GPa.
2009 Jul 25
Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides.
2010 Apr 22
Application of spectroscopic methods for structural analysis of chitin and chitosan.
2010 Apr 29
Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats.
2010 Jan
Antibacterial nitric oxide-releasing polyester for the coating of blood-contacting artificial materials.
2010 Jul
All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms.
2010 Jul 13
cpSRP43 is a novel chaperone specific for light-harvesting chlorophyll a,b-binding proteins.
2010 Jul 9
Recovery of CdS nanocrystal defects through conjugation with proteins.
2010 Jun 15
The leukemia associated ETO nuclear repressor gene is regulated by the GATA-1 transcription factor in erythroid/megakaryocytic cells.
2010 May 20
Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling.
2010 Nov 10
Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.
2010 Nov 15
Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions.
2010 Nov 30
Thiol-functionalized copolymeric polyesters by lipase-catalyzed esterification and transesterification of 1,12-dodecanedioic acid and its diethyl ester, respectively, with 1-thioglycerol.
2010 Oct
Controlled assembly of Janus nanoparticles.
2010 Sep 21
Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.
2011 Mar 15
Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2: Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line.
2015 Nov 1
Patents

Patents

04297513
2
04877899
4
05116869
1
05395752
3
05734081
3

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
1.5 × 10^7 spleen cells/ml were incubated in 3 ml with or without 2-ME or aTG (Monothioglycerol) in serum-free or 5% fetal calf serum (FCS)-containing media. PFC's to sheep red blood cells (SRBC) and trinitrophenyl (TNP) were assayed at day 2 of culture using a modification of the hemolytic plaque assay of Jerne and Nordin. The number of TNP-specific plaques was calculated by subtracting the PFC response to goat red blood cells (GRBC) from the response to TNP-GRBC.
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:09:02 GMT 2023
Edited
by admin
on Sat Dec 16 05:09:02 GMT 2023
Record UNII
AAO1P0WSXJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MONOTHIOGLYCEROL
HSDB   II   MART.   VANDF  
Systematic Name English
MONOTHIOGLYCEROL [HSDB]
Common Name English
3-Mercapto-1,2-propanediol
Systematic Name English
NSC-5370
Code English
THIOGLYCERIN
INCI  
INCI  
Official Name English
THIOGLYCEROL [MI]
Common Name English
1-THIO-DL-GLYCEROL
Common Name English
MONOTHIOGLYCEROL [II]
Common Name English
DL-1-THIOGLYCEROL
Common Name English
1,2-PROPANEDIOL, 3-MERCAPTO-
Systematic Name English
(±)-3-MERCAPTO-1,2-PROPANEDIOL
Systematic Name English
.ALPHA.-THIOGLYCEROL
Common Name English
MONOTHIOGLYCEROL [VANDF]
Common Name English
THIOGLYCEROL
MI   VANDF  
Systematic Name English
THIOGLYCEROL [VANDF]
Common Name English
1-THIOGLYCEROL
Systematic Name English
THIOGLYCERIN [INCI]
Common Name English
MONOTHIOGLYCEROL [MART.]
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL1398948
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
EVMPD
SUB72519
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
HSDB
2184
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
CHEBI
74537
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
CONCEPT Industrial Aid
CAS
96-27-5
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
WIKIPEDIA
3-Mercaptopropane-1,2-diol
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
NCI_THESAURUS
C77509
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
SMS_ID
100000135869
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
ECHA (EC/EINECS)
202-495-0
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
FDA UNII
AAO1P0WSXJ
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
MESH
C009465
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
RXCUI
1363062
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY RxNorm
EPA CompTox
DTXSID5046512
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
DRUG BANK
DB03864
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
DAILYMED
AAO1P0WSXJ
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
NSC
5370
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
MERCK INDEX
m10758
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY Merck Index
PUBCHEM
7291
Created by admin on Sat Dec 16 05:09:02 GMT 2023 , Edited by admin on Sat Dec 16 05:09:02 GMT 2023
PRIMARY
NIH
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