IRTEMAZOLE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H16N4
Molecular Weight	288.3464
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC2=C(N1)C=C(C=C2)C(N3C=CN=C3)C4=CC=CC=C4

InChI

InChIKey=DCGOMTSIZLGUOK-UHFFFAOYSA-N

InChI=1S/C18H16N4/c1-13-20-16-8-7-15(11-17(16)21-13)18(22-10-9-19-12-22)14-5-3-2-4-6-14/h2-12,18H,1H3,(H,20,21)

HIDE SMILES / InChI

Molecular Formula	C18H16N4
Molecular Weight	288.3464
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2615290 | https://www.ncbi.nlm.nih.gov/pubmed/2586012

IRTEMAZOLE is a uricosuric agent exhibiting a rapid uricosuric effect in normouricemic as well as in hyperuricemic persons.

Originator

Approval Year

PubMed

Title	Date	PubMed
Rapid onset of uricosuria after oral administration of irtemazole, an uricosuric substance.	1989-10-17	2586012
Uricosuric effect of irtemazole in healthy subjects.	1989-10-02	2615290
A new uricosuric substance 5-[(1H-imidazol-1-yl)phenylmethyl]-2-methyl-1H-benzimidazole (C18H16N4).	1989-06-15	2770180

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:33:27 GMT 2025` Edited by `admin` on `Mon Mar 31 18:33:27 GMT 2025`
Record UNII	AAK27WY74I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

R-60844

Preferred Name

English

IRTEMAZOLE

Official Name

English

IRTEMAZOLE [USAN]

Common Name

English

1H-BENZIMIDAZOLE, 5-(1H-IMIDAZOL-1-YLPHENYLMETHYL)-2-METHYL-

Systematic Name

English

1H-BENZIMIDAZOLE, 5-(1H-IMIDAZOL-1-YLPHENYLMETHYL)-2-METHYL-, (±)-

Common Name

English

(±)-5-(.ALPHA.-IMIDAZOL-1-YLBENZYL)-2-METHYLBENZIMIDAZOLE

Common Name

English

1H-BENZIMIDAZOLE, 6-(1H-IMIDAZOL-1-YLPHENYLMETHYL)-2-METHYL-

Systematic Name

English

irtemazole [INN]

Common Name

English

R60844

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C921