Ristoglogene autogetemcel mRNA

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 18:46:38 GMT 2025` Edited by `admin` on `Wed Apr 02 18:46:38 GMT 2025`
Nucleic Acid Type	MRNA
Sequence Type	COMPLETE
Record UNII	AAF4LU29JC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Ristoglogene autogetemcel mRNA

Common Name

English

ABE8.8 mRNA

Preferred Name

English

ABE8.8 mRNA (Composed of three parts: (i) an impaired form of the Streptococcus pyogenes CRISPR-associated nuclease Cas9, referred to as Cas9 D10A nickase (nCas9-D10A), (ii) an Escherichia coli derived TadA deaminase that catalyses the adenosine to inosi

Common Name

English

Code System Code Type Description

FDA UNII

AAF4LU29JC

Created by admin on Wed Apr 02 18:46:38 GMT 2025 , Edited by admin on Wed Apr 02 18:46:38 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_5035	5035 / 5035

Linkage	Site Range	Site Count
Phosphate	1_2-1_5035	5034 / 5034

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION		RESIDUE_SPECIFIC	U		N1-METHYLPSEUDOURIDINE	09RAD4M6WF
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS	A		7M-G-PPP-2'M-A-P MRNA CAP	P7W5ZN6FY2

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
PolyA	NUCLEIC ACID FEATURE

3’UTR	NUCLEIC ACID FEATURE

ORF	NUCLEIC ACID FEATURE

5’UTR	NUCLEIC ACID FEATURE