DIQUAT

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H12N2
Molecular Weight	184.2371
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	2

SHOW SMILES / InChI

Structure Search

SMILES

C1C[N+]2=C(C=CC=C2)C3=CC=CC=[N+]13

InChI

InChIKey=SYJFEGQWDCRVNX-UHFFFAOYSA-N

InChI=1S/C12H12N2/c1-3-7-13-9-10-14-8-4-2-6-12(14)11(13)5-1/h1-8H,9-10H2/q+2

HIDE SMILES / InChI

Molecular Formula	C12H12N2
Molecular Weight	184.2371
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Effects of oxidative stress caused by hyperoxia and diquat. A study in isolated hepatocytes.	1986	3505239
Upregulation of glucose-6-phosphate dehydrogenase in response to hepatocellular oxidative stress: studies with diquat.	1995 Dec	8934631
Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress.	1999 Sep	10490281
Glutathione peroxidase-1 gene knockout on body antioxidant defense in mice.	2001	11568445
Lipopolysaccharide and interferon-gamma-induced nitric oxide production and protein oxidation in mouse peritoneal macrophages are affected by glutathione peroxidase-1 gene knockout.	2001 Aug 15	11498278
Tetracyanometalates of Ni, Pd, and Pt with cyclic diquaternary cations of 2,2'-bipyridine and 1,10-phenanthroline. A vibrational, crystallographic, and theoretical study of intermolecular weak interactions.	2002 Aug 26	12184756
Role of capsaicin-sensitive afferent nerves in different models of gastric inflammation in rats.	2004 Feb 27	15046732
Compartmental inhibition of hepatic glutathione reductase activities by 1,3-bis(2-chloroethyl)-N-nitrosourea (BCNU) in Sprague-Dawley and Fischer-344 rats.	2004 Mar 7	15104113
Protective effects of wheat bran against diquat toxicity in male Fischer-344 rats.	2007 Jul	17617720
Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia.	2007 Nov 1	17893043
The in vivo gene expression signature of oxidative stress.	2008 Jun 12	18445702
Long-lived ames dwarf mice are resistant to chemical stressors.	2009 Aug	19414510
Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions.	2009 Nov 6	19744930
Evaluation of transcriptional activity of caspase-3 gene as a marker of acute neurotoxicity in rat cerebellar granular cells.	2010 Mar	19815060
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.	2010 Mar 15	20143881
Hepatic response to oxidative injury in long-lived Ames dwarf mice.	2011 Jan	20826540
Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway.	2012	23056183
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.	2013 Jun	22954530
Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria.	2015 Oct	25693864

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:14:14 UTC 2023` Edited by `admin` on `Fri Dec 15 15:14:14 UTC 2023`
Record UNII	A9A615U4MP
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DIQUAT

Common Name

English

6,7-DIHYDRODIPYRIDO(1,2-A:2',1'-C)PYRAZINEDIIUM

Systematic Name

English

9,10-DIHYDRO-8A,10A-DIAZONIAPHENANTHRENE

Common Name

English

DIQUAT [ISO]

Common Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

32202