VUPANORSEN

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National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Tue Apr 01 23:26:54 GMT 2025` Edited by `admin` on `Tue Apr 01 23:26:54 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Type	COMPLETE
Record UNII	A7YG62NHZ6
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AKCEA-ANGPTL3-LRX

Preferred Name

English

VUPANORSEN

Official Name

English

VUPANORSEN [USAN]

Common Name

English

ISIS-703802

Code

English

DNA, D((2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-T-SP-T-SP-G-SP-M5C-SP-M5C-SP-A-SP-G-SP-T-SP-A-SP-A-SP-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RC-(2

Systematic Name

English

ALL-P-AMBO-5-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXOXY))PHOSPHO)-2-O-(2-METHOXYETHYL)-P-THIOGUANYLYL-(3-O->5-O)-2-O-(2-METHOXYETHYL)GUANYLYL-(3-O->5-O)-2-O

Systematic Name

English

ISIS 703802

Code

English

vupanorsen [INN]

Common Name

English

Code System Code Type Description

FDA UNII

A7YG62NHZ6

Created by admin on Tue Apr 01 23:26:54 GMT 2025 , Edited by admin on Tue Apr 01 23:26:54 GMT 2025

PRIMARY

INN

11175

Created by admin on Tue Apr 01 23:26:54 GMT 2025 , Edited by admin on Tue Apr 01 23:26:54 GMT 2025

PRIMARY

CAS

2097587-62-5

Created by admin on Tue Apr 01 23:26:54 GMT 2025 , Edited by admin on Tue Apr 01 23:26:54 GMT 2025

PRIMARY

SMS_ID

300000010320

Created by admin on Tue Apr 01 23:26:54 GMT 2025 , Edited by admin on Tue Apr 01 23:26:54 GMT 2025

PRIMARY

USAN

FG-167

Created by admin on Tue Apr 01 23:26:54 GMT 2025 , Edited by admin on Tue Apr 01 23:26:54 GMT 2025

PRIMARY

NCI_THESAURUS

C174612

Created by admin on Tue Apr 01 23:26:54 GMT 2025 , Edited by admin on Tue Apr 01 23:26:54 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_6-1_15	10 / 20
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20

Linkage	Site Range	Site Count
Phosporothioate	1_1;1_6-1_15;1_18-1_19	13 / 19
Phosphate	1_2-1_5;1_16-1_17	6 / 19

Related Record Type Details


					A7YG62NHZ6

PARENT -> SALT/SOLVATE


					WKQ0PJ4VMZ

ANGIOPOIETIN-RELATED PROTEIN 3

TARGET->INHIBITOR OF EXPRESSION

Related Record Type Details


					A7YG62NHZ6

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_4] [1_17] [1_19]	SITE_SPECIFIC			2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE	AOQ54IZZ6J
NUCLEOSIDE_SUBSTITUTION	[1_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	91ce9173 (not in database)
NUCLEOSIDE_SUBSTITUTION	[1_9] [1_10]	SITE_SPECIFIC			5-METHYLDEOXYCYTIDINE	B200GV71QM

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL