U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 14:23:40 UTC 2023
Edited
by admin
on Sat Dec 16 14:23:40 UTC 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type COMPLETE
Record UNII
A7YG62NHZ6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VUPANORSEN
INN   USAN  
Official Name English
AKCEA-ANGPTL3-LRX
Code English
VUPANORSEN [USAN]
Common Name English
ISIS-703802
Code English
DNA, D((2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-T-SP-T-SP-G-SP-M5C-SP-M5C-SP-A-SP-G-SP-T-SP-A-SP-A-SP-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RC-(2
Systematic Name English
ALL-P-AMBO-5-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXOXY))PHOSPHO)-2-O-(2-METHOXYETHYL)-P-THIOGUANYLYL-(3-O->5-O)-2-O-(2-METHOXYETHYL)GUANYLYL-(3-O->5-O)-2-O
Systematic Name English
ISIS 703802
Code English
vupanorsen [INN]
Common Name English
Code System Code Type Description
FDA UNII
A7YG62NHZ6
Created by admin on Sat Dec 16 14:23:40 UTC 2023 , Edited by admin on Sat Dec 16 14:23:40 UTC 2023
PRIMARY
INN
11175
Created by admin on Sat Dec 16 14:23:40 UTC 2023 , Edited by admin on Sat Dec 16 14:23:40 UTC 2023
PRIMARY
CAS
2097587-62-5
Created by admin on Sat Dec 16 14:23:40 UTC 2023 , Edited by admin on Sat Dec 16 14:23:40 UTC 2023
PRIMARY
USAN
FG-167
Created by admin on Sat Dec 16 14:23:40 UTC 2023 , Edited by admin on Sat Dec 16 14:23:40 UTC 2023
PRIMARY
NCI_THESAURUS
C174612
Created by admin on Sat Dec 16 14:23:40 UTC 2023 , Edited by admin on Sat Dec 16 14:23:40 UTC 2023
PRIMARY
Sugar Site Range Site Count
Deoxyribose (DNA) 1_6-1_15 10 / 20
2'-O-Methoxyethyl ribose 1_1-1_5;1_16-1_20 10 / 20
Linkage Site Range Site Count
Phosporothioate 1_1;1_6-1_15;1_18-1_19 13 / 19
Phosphate 1_2-1_5;1_16-1_17 6 / 19
Related Record Type Details
PARENT -> SALT/SOLVATE
TARGET->INHIBITOR OF EXPRESSION
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE_SUBSTITUTION [1_4] [1_17] [1_19] SITE_SPECIFIC 2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE AOQ54IZZ6J
NUCLEOSIDE_SUBSTITUTION [1_1] 5'-TERMINUS UNSPECIFIED SUBSTANCE
91ce9173
(not in database)
NUCLEOSIDE_SUBSTITUTION [1_9] [1_10] SITE_SPECIFIC 5-METHYLDEOXYCYTIDINE B200GV71QM
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL