Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C10H14N2O5 |
Molecular Weight | 241.2293 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)[11C](=O)NC1=O
InChI
InChIKey=IQFYYKKMVGJFEH-CNZKURHESA-N
InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1/i10-1
Molecular Formula | C10H14N2O5 |
Molecular Weight | 241.2293 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
PET imaging using 2-[11C]thymidine (dThd) was developed as a measure of tumor proliferation and cancer response to treatment. The drug was tested on patients with brain tumors. A PET image is a result of the metabolic processes for delivery, uptake, and retention in DNA by the tumor and degradative metabolism in the whole patient. 2-[11C]Thymidine is metabolized to [C11]CO2, which rapidly crosses the blood-brain barrier and distributes throughout the brain. 2-[11C]Thymidine itself is poorly transported by the blood-brain barrier, however, it may intercalate into DNA.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9973209
Curator's Comment: Poorly transported across the blood-brain barrier.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2311221 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9973209 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Diagnostic | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9973209
For PET imaging in patients with brain tumors, ten to 20 mCi 2-(C-11)thymidine was infused i.v. for 60 s using a Harvard infusion pump.
Route of Administration:
Intravenous
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:00:42 GMT 2023
by
admin
on
Fri Dec 15 17:00:42 GMT 2023
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Record UNII |
A775ZPE88B
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C2124
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admin on Fri Dec 15 17:00:42 GMT 2023 , Edited by admin on Fri Dec 15 17:00:42 GMT 2023
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DTXSID00156455
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A775ZPE88B
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130333-77-6
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12359148
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C90936
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admin on Fri Dec 15 17:00:42 GMT 2023 , Edited by admin on Fri Dec 15 17:00:42 GMT 2023
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