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Details

Stereochemistry ACHIRAL
Molecular Formula C24H24FN3O2.C6H6O3S
Molecular Weight 563.64
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of KX2-361 BESYLATE

SMILES

OS(=O)(=O)C1=CC=CC=C1.FC2=CC=CC(CNC(=O)CC3=CC=C(C=N3)C4=CC=C(C=C4)N5CCOCC5)=C2

InChI

InChIKey=PTKRPOIHIOAMPP-UHFFFAOYSA-N
InChI=1S/C24H24FN3O2.C6H6O3S/c25-21-3-1-2-18(14-21)16-27-24(29)15-22-7-4-20(17-26-22)19-5-8-23(9-6-19)28-10-12-30-13-11-28;7-10(8,9)6-4-2-1-3-5-6/h1-9,14,17H,10-13,15-16H2,(H,27,29);1-5H,(H,7,8,9)

HIDE SMILES / InChI
Molecular Formula C6H6O3S
Molecular Weight 158.175
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C24H24FN3O2
Molecular Weight 405.4647
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

KX-02 is a compound demonstrating dual inhibitory activity against Src kinase and tubulin polymerization. It readily crosses the blood-brain-barrier in mice. It is under development for the treatment of solid tumors.

CNS Activity

CNS Penetrant
2588
Curator's Comment: Known to be CNS penetrant in mice. Human data not available.

Originator

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma.
2018-12
Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361).
2018-06-14
Substance Class Chemical
Created
by admin
on Tue Apr 01 16:26:56 GMT 2025
Edited
by admin
on Tue Apr 01 16:26:56 GMT 2025
Record UNII
A718CYC1N0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
KX2-361 BESYLATE
Common Name English
N-(3-FLUOROBENZYL)-2-(5-(4-MORPHOLINOPHENYL) PYRIDIN-2-YL) ACETAMIDE BESYLATE
Preferred Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 413513
Created by admin on Tue Apr 01 16:26:56 GMT 2025 , Edited by admin on Tue Apr 01 16:26:56 GMT 2025
Code System Code Type Description
PUBCHEM
73334909
Created by admin on Tue Apr 01 16:26:56 GMT 2025 , Edited by admin on Tue Apr 01 16:26:56 GMT 2025
PRIMARY
CAS
1571072-87-1
Created by admin on Tue Apr 01 16:26:56 GMT 2025 , Edited by admin on Tue Apr 01 16:26:56 GMT 2025
PRIMARY
FDA UNII
A718CYC1N0
Created by admin on Tue Apr 01 16:26:56 GMT 2025 , Edited by admin on Tue Apr 01 16:26:56 GMT 2025
PRIMARY
Related Record Type Details
Structure of KX2-361
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of KX2-361
ACTIVE MOIETY
NIH
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