NORVALINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C5H11NO2
Molecular Weight	117.1463
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC[C@H](N)C(O)=O

InChI

InChIKey=SNDPXSYFESPGGJ-BYPYZUCNSA-N

InChI=1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C5H11NO2
Molecular Weight	117.1463
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Proton-coupled amino acid transporter 1 1 Target ID: CHEMBL1914279 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21955456	Interacts 323		46.0 mM [Ki]

PubMed

Title	Date	PubMed
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.	2001 Feb 1	11221839
Conversion of a glutamate dehydrogenase into methionine/norleucine dehydrogenase by site-directed mutagenesis.	2001 Nov	11722565
Arginine deprivation and tumour cell death: arginase and its inhibition.	2003 Feb	12701828
Two new cyclosporin folds observed in the structures of the immunosuppressant cyclosporin G and the formyl peptide receptor antagonist cyclosporin H at ultra-high resolution.	2003 May 7	12926274
Arginase pathway in human endothelial cells in pathophysiological conditions.	2004 Aug	15276021
Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.	2008 Jun 19	18565210
RNAi-mediated suppression of isoprene emission in poplar transiently impacts phenolic metabolism under high temperature and high light intensities: a transcriptomic and metabolomic analysis.	2010 Sep	20526857

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:31:25 UTC 2023` Edited by `admin` on `Fri Dec 15 16:31:25 UTC 2023`
Record UNII	A70UKS48FE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NORVALINE

Official Name

English

Norvaline [WHO-DD]

Common Name

English

(S)-2-AMINOVALERIC ACID

Systematic Name

English

(S)-2-AMINOPENTANOIC ACID

Systematic Name

English

(S)-(+)-2-AMINOPENTANOIC ACID

Systematic Name

English

L-.ALPHA.-AMINOVALERIC ACID

Common Name

English

L-NORVALINE

Systematic Name

English

NORVALINE [MI]

Common Name

English

NORVALINE [INCI]

Common Name

English

NSC-203786

Code

English

NORVALINE, L-

Systematic Name

English

2S-AMINOVALERIC ACID

Common Name

English

Classification Tree Code System Code

DSLD

1076 (Number of products:82)